UM
Markers of glycemic control in the mouse: Comparisons of 6-h-and overnight-fasted blood glucoses to Hb A1c
Han B.G.1; Hao C.-M.1; Tchekneva E.E.1; Wang Y.-Y.1; Chieh A.L.3; Ebrahim B.1; Harris R.C.1; Kern T.S.3; Wasserman D.H.1; Breyer M.D.1; Qi Z.1
2008-10-01
Source PublicationAmerican Journal of Physiology - Endocrinology and Metabolism
ISSN01931849 15221555
Volume295Issue:4
AbstractThe present studies examined the relationship between fasting blood glucose and Hb A in C57BL/6J, DBA/2J, and KK/HlJ mice with and without diabetes mellitus. Daily averaged blood glucose levels based on continuous glucose monitoring and effects of 6-h vs. overnight fasting on blood glucose were determined. Daily averaged blood glucose levels were highly correlated with Hb A, as determined with a hand-held automated device using an immunodetection method. R values were 0.90, 0.95, and 0.99 in KK/HIJ, C57BL/6J, and DBA/2J, respectively. Six-hour fasting blood glucose correlated more closely with the level of daily averaged blood glucose and with Hb A than did blood glucose following an overnight fast. To validate the immunoassay-determined Hb A, we also measured total glycosylated hemoglobin using boronate HPLC. Hb A values correlated well with total glycosylated hemoglobin in all three strains but were relatively lower than total glycosylated hemoglobin in diabetic DBA/2J mice. These results show that 6-h fasting glucose provides a superior index of glycemic control and correlates more closely with Hb A than overnight-fasted blood glucose in these strains of mice. Copyright © 2008 the American Physiological Society.
KeywordGlycosylated hemoglobin Methodology Mice
DOI10.1152/ajpendo.90283.2008
URLView the original
Language英語
Fulltext Access
Citation statistics
Cited Times [WOS]:33   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Vanderbilt University
2.Eli Lilly and Company
3.Case Western Reserve University
4.Vanderbilt University School of Medicine
Recommended Citation
GB/T 7714
Han B.G.,Hao C.-M.,Tchekneva E.E.,et al. Markers of glycemic control in the mouse: Comparisons of 6-h-and overnight-fasted blood glucoses to Hb A1c[J]. American Journal of Physiology - Endocrinology and Metabolism,2008,295(4).
APA Han B.G..,Hao C.-M..,Tchekneva E.E..,Wang Y.-Y..,Chieh A.L..,...&Qi Z..(2008).Markers of glycemic control in the mouse: Comparisons of 6-h-and overnight-fasted blood glucoses to Hb A1c.American Journal of Physiology - Endocrinology and Metabolism,295(4).
MLA Han B.G.,et al."Markers of glycemic control in the mouse: Comparisons of 6-h-and overnight-fasted blood glucoses to Hb A1c".American Journal of Physiology - Endocrinology and Metabolism 295.4(2008).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Han B.G.]'s Articles
[Hao C.-M.]'s Articles
[Tchekneva E.E.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Han B.G.]'s Articles
[Hao C.-M.]'s Articles
[Tchekneva E.E.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Han B.G.]'s Articles
[Hao C.-M.]'s Articles
[Tchekneva E.E.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.