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Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier
Wang Y.-Y.; Lai S.K.; Suk J.S.; Pace A.; Cone R.; Hanes J.
2008-12-01
Source PublicationAngewandte Chemie - International Edition
ISSN14337851
Volume47Issue:50Pages:9726-9729
Abstract(Figure Presented) Outsmarting the barrier: Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by adhesive interactions (red) with the mucus mesh (black lines). A dense, low molecular weight PEG coating (blue) uniquely endows nanoparticles with a mucoinert surface that enables their rapid mucus penetration (trajectory indicated by grey line). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
KeywordDrug delivery Mucosal tissues Nanomedicine Particle tracking Surface chemistry
DOI10.1002/anie.200803526
URLView the original
Language英語
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Cited Times [WOS]:326   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationJohns Hopkins University
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GB/T 7714
Wang Y.-Y.,Lai S.K.,Suk J.S.,et al. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier[J]. Angewandte Chemie - International Edition,2008,47(50):9726-9729.
APA Wang Y.-Y.,Lai S.K.,Suk J.S.,Pace A.,Cone R.,&Hanes J..(2008).Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier.Angewandte Chemie - International Edition,47(50),9726-9729.
MLA Wang Y.-Y.,et al."Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier".Angewandte Chemie - International Edition 47.50(2008):9726-9729.
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