UM
Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2
Duncton M.A.J.; Piatnitski Chekler E.L.; Katoch-Rouse R.; Sherman D.; Wong W.C.; Smith II L.M.; Kawakami J.K.; Kiselyov A.S.; Milligan D.L.; Balagtas C.; Hadari Y.R.; Wang Y.; Patel S.N.; Rolster R.L.; Tonra J.R.; Surguladze D.; Mitelman S.; Kussie P.; Bohlen P.; Doody J.F.
2009-01-15
Source PublicationBioorganic and Medicinal Chemistry
ISSN09680896
Volume17Issue:2Pages:731-740
AbstractA series of arylphthalazine derivatives were synthesized and evaluated as antagonists of VEGF receptor II (VEGFR-2). IM-094482 57, which was prepared in two steps from commercially available starting materials, was found to be a potent inhibitor of VEGFR-2 in enzymatic, cellular and mitogenic assays (comparable activity to ZD-6474). Additionally, 57 inhibited the related receptor, VEGF receptor I (VEGFR-1), and showed excellent exposure when dosed orally to female CD-1 mice. © 2008 Elsevier Ltd. All rights reserved.
KeywordAngiogenesis Arylphthalazine Inhibitor KDR Kinase Phthalazine VEGFR-2
DOI10.1016/j.bmc.2008.11.049
URLView the original
Language英語
Fulltext Access
Citation statistics
Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationEli Lilly and Company
Recommended Citation
GB/T 7714
Duncton M.A.J.,Piatnitski Chekler E.L.,Katoch-Rouse R.,et al. Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2[J]. Bioorganic and Medicinal Chemistry,2009,17(2):731-740.
APA Duncton M.A.J..,Piatnitski Chekler E.L..,Katoch-Rouse R..,Sherman D..,Wong W.C..,...&Doody J.F..(2009).Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2.Bioorganic and Medicinal Chemistry,17(2),731-740.
MLA Duncton M.A.J.,et al."Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2".Bioorganic and Medicinal Chemistry 17.2(2009):731-740.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Duncton M.A.J.]'s Articles
[Piatnitski Chekler E.L.]'s Articles
[Katoch-Rouse R.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Duncton M.A.J.]'s Articles
[Piatnitski Chekler E.L.]'s Articles
[Katoch-Rouse R.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Duncton M.A.J.]'s Articles
[Piatnitski Chekler E.L.]'s Articles
[Katoch-Rouse R.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.