UM
Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor
Liu D.1; Yin C.2; Zhang Y.1; Tian L.2; Li T.1; Li D.2; Ma D.2; Guo Y.1; Wang Y.2
2009-03-01
Source PublicationChinese Science Bulletin
ISSN10016538 18619541
Volume54Issue:6Pages:1050-1057
AbstractCKLF (chemokine-like factor)-like MARVEL (MAL and related proteins for vesicle trafficking and membrane link domain) transmembrane domain containing (CMTM) is a novel gene family. One member of this family, CMTM2, also named chemokine-like factor superfamily 2 (CKLFSF2), is expressed highly in the testis and moderately in the prostate, marrow and peripheral blood cells. However, the function of human CMTM2 remains unknown. Here, we found that CMTM2 was upregulated in 5α-dihydrotestosterone (DHT)-treated LNCaP cells. We investigated the relationship between CMTM2 and the androgen receptor. Our results showed that CMTM2 enhanced DHT-mediated androgen receptor (AR) transactivation and the expression of prostate specific antigen (PSA). We also observed that CMTM2 enhanced the AR protein level, which was reversed by silencing endogenous CMTM2 expression, which suggested that CMTM2 might play an important role in maintaining the AR protein level. We also found that CMTM2 suppressed Akt activation. A previous study showed that Akt could phosphorylate AR at Ser210 and Ser790 and lead to AR ubiquitylation and degradation as well as suppression of AR activity. Taken together, suppressing Akt activation and increasing the AR protein level might be one of the mechanisms for the CMTM2-mediated enhancement of AR transactivation. © 2009 Science in China Press and Springer-Verlag GmbH.
KeywordAkt Androgen receptor CKLFSF2 CMTM2 Transactivation
DOI10.1007/s11434-009-0092-8
URLView the original
Language英語
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Peking University
2.Peking University Health Science Center
3.Tianjin Medical University
Recommended Citation
GB/T 7714
Liu D.,Yin C.,Zhang Y.,et al. Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor[J]. Chinese Science Bulletin,2009,54(6):1050-1057.
APA Liu D..,Yin C..,Zhang Y..,Tian L..,Li T..,...&Wang Y..(2009).Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor.Chinese Science Bulletin,54(6),1050-1057.
MLA Liu D.,et al."Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor".Chinese Science Bulletin 54.6(2009):1050-1057.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu D.]'s Articles
[Yin C.]'s Articles
[Zhang Y.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu D.]'s Articles
[Yin C.]'s Articles
[Zhang Y.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu D.]'s Articles
[Yin C.]'s Articles
[Zhang Y.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.