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Vasoactive intestinal peptide attenuates concanavalin A-mediated liver injury
Luo Q.2; Wang Y.2; Feng D.1; Xu Y.1; Xu L.2
2009-04-01
Source PublicationEuropean Journal of Pharmacology
ISSN00142999
Volume607Issue:1-3Pages:226-233
AbstractVasoactive intestinal peptide (VIP) is well characterized as an endogenous anti-inflammatory neuropeptide and has a brand range of biological functions. In this study, we found increased endogenous VIP expression in mice with concanavalin A-induced hepatitis, a widely used experimental model of immune-mediated liver injury. We investigated further the effect of VIP administration on concanavalin A-induced liver injury. Compared with mice pretreated with PBS, mice pretreated with VIP exhibited much lower plasma levels of aminotransferases, less inflammatory infiltration in the liver and hepatocyte apoptosis. Meanwhile, VIP significantly inhibited the release of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in concanavalin A-injected mice, but markedly elevated the production of anti-inflammatory cytokine interleukine-10 (IL-10). Further investigation demonstrated increased intracellular cAMP concentration after VIP administration, and showed that the protective effect of VIP on concanavalin A-induced hepatitis was mediated mainly through VIP receptor 1 (VPAC). These results suggest that VIP is capable of attenuating immune-mediated liver injury in vivo. This effect is associated with its downregulation of critical inflammatory mediators and its upregulation of anti-inflammatory cytokine through VPAC, possibly via the cAMP-dependent pathway. © 2009 Elsevier B.V. All rights reserved.
KeywordcAMP Concanavalin A Hepatitis Vasoactive intestinal peptide VIP receptor 1
DOI10.1016/j.ejphar.2009.02.012
URLView the original
Language英語
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Institute for Biological Sciences Chinese Academy of Sciences
2.Shanghai Jiao Tong University
Recommended Citation
GB/T 7714
Luo Q.,Wang Y.,Feng D.,et al. Vasoactive intestinal peptide attenuates concanavalin A-mediated liver injury[J]. European Journal of Pharmacology,2009,607(1-3):226-233.
APA Luo Q.,Wang Y.,Feng D.,Xu Y.,&Xu L..(2009).Vasoactive intestinal peptide attenuates concanavalin A-mediated liver injury.European Journal of Pharmacology,607(1-3),226-233.
MLA Luo Q.,et al."Vasoactive intestinal peptide attenuates concanavalin A-mediated liver injury".European Journal of Pharmacology 607.1-3(2009):226-233.
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