Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation | |
Li, Chuwen1; Chen, Tongkai2; Zhou, Hefeng1; Zhang, Chao1,3; Feng, Yu1; Tang, Fan1; Hoi, Maggie Pui-Man1; He, Chengwei1![]() ![]() ![]() | |
2018 | |
Source Publication | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
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ISSN | 1015-8987 |
Volume | 47Issue:5Pages:1769-1784 |
Abstract | Background/Aims: In the present study, we investigated whether schisantherin A (StA) had anti-inflammatory effects under neuroinflammatory conditions. Methods: The effects of StA and its underlying mechanisms were examined in lipopolysaccharide (LPS)-activated BV-2 microglial cells by ELISA, qPCR, EMSA, Western blot, and IHC. Results: Firstly, we found that StA inhibited the inflammatory response in LPS-activated BV-2 microglia. Secondly, we found that StA suppressed LPS-induced activation of NF-kappa B via interfering with degradation of I kappa B and phosphorylation of I kappa B, IKK, PI3K/Akt, JNK, and p38 MAPK. Thirdly, StA conferred indirect antioxidative effects via quenching ROS and promoted expression of antioxidant enzymes, including HO-1 and NQO-1, via stimulating activation of Nrf2 pathways. Finally, we demonstrated that anti-neuroinflammatory actions of StA were dependent on ERK phosphorylation-mediated Nrf2 activation. Conclusion: StA induced ERK phosphorylation-mediated Nrf2 activation, which contributed to its anti-inflammation and anti-oxidation. The anti-neuroinflammatory and anti-oxidative effects of StA may show preventive therapeutic potential for various neuroinflammatory disorders. |
Keyword | Schisantherin a Neuroinflammation Microglia Nrf2 Nf-kappa b |
DOI | https://doi.org/10.1159/000491059 |
URL | View the original |
Indexed By | SCI |
Language | 英语 |
WOS Research Area | Cell Biology ; Physiology |
WOS Subject | Cell Biology ; Physiology |
WOS ID | WOS:000440149600002 |
Publisher | KARGER |
The Source to Article | WOS |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences |
Corresponding Author | Lee, Simon Ming-Yuen |
Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China 2.Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China 3.School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China |
First Author Affilication | Institute of Chinese Medical Sciences |
Corresponding Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Li, Chuwen,Chen, Tongkai,Zhou, Hefeng,et al. Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2018,47(5):1769-1784. |
APA | Li, Chuwen.,Chen, Tongkai.,Zhou, Hefeng.,Zhang, Chao.,Feng, Yu.,...&Lee, Simon Ming-Yuen.(2018).Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation.CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,47(5),1769-1784. |
MLA | Li, Chuwen,et al."Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 47.5(2018):1769-1784. |
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