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Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation
Li, Chuwen1; Chen, Tongkai2; Zhou, Hefeng1; Zhang, Chao1,3; Feng, Yu1; Tang, Fan1; Hoi, Maggie Pui-Man1; He, Chengwei1; Zheng, Ying1; Lee, Simon Ming-Yuen1
2018
Source PublicationCELLULAR PHYSIOLOGY AND BIOCHEMISTRY
ISSN1015-8987
Volume47Issue:5Pages:1769-1784
Abstract

Background/Aims: In the present study, we investigated whether schisantherin A (StA) had anti-inflammatory effects under neuroinflammatory conditions. Methods: The effects of StA and its underlying mechanisms were examined in lipopolysaccharide (LPS)-activated BV-2 microglial cells by ELISA, qPCR, EMSA, Western blot, and IHC. Results: Firstly, we found that StA inhibited the inflammatory response in LPS-activated BV-2 microglia. Secondly, we found that StA suppressed LPS-induced activation of NF-kappa B via interfering with degradation of I kappa B and phosphorylation of I kappa B, IKK, PI3K/Akt, JNK, and p38 MAPK. Thirdly, StA conferred indirect antioxidative effects via quenching ROS and promoted expression of antioxidant enzymes, including HO-1 and NQO-1, via stimulating activation of Nrf2 pathways. Finally, we demonstrated that anti-neuroinflammatory actions of StA were dependent on ERK phosphorylation-mediated Nrf2 activation. Conclusion: StA induced ERK phosphorylation-mediated Nrf2 activation, which contributed to its anti-inflammation and anti-oxidation. The anti-neuroinflammatory and anti-oxidative effects of StA may show preventive therapeutic potential for various neuroinflammatory disorders. (C) 2018 The Author(s) Published by S. Karger AG, Basel

KeywordSchisantherin a Neuroinflammation Microglia Nrf2 Nf-kappa b
DOI10.1159/000491059
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Physiology
WOS SubjectCell Biology ; Physiology
WOS IDWOS:000440149600002
PublisherKARGER
The Source to ArticleWOS
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLee, Simon Ming-Yuen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China
3.School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li, Chuwen,Chen, Tongkai,Zhou, Hefeng,et al. Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2018,47(5):1769-1784.
APA Li, Chuwen.,Chen, Tongkai.,Zhou, Hefeng.,Zhang, Chao.,Feng, Yu.,...&Lee, Simon Ming-Yuen.(2018).Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation.CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,47(5),1769-1784.
MLA Li, Chuwen,et al."Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 47.5(2018):1769-1784.
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