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Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies
Wang Y.F.1; Shi L.1; Song Q.S.1; Zhang Y.M.1; Lou Y.X.1; Zheng Y.1; Ma D.L.1; Wang Y.1; Ke X.Y.1
2009-11-01
Source PublicationChinese Science Bulletin
ISSN10016538 18619541
Volume54Issue:21Pages:3981-3989
AbstractPDCD5 is a novel apoptosis-related gene. Overexpression of PDCD5 facilitates apoptosis in various tumor cells. Here, we investigated the roles of recombinant human PDCD5 (rhPDCD5) protein in chemosensitivities of hematologic malignancies. The rhPDCD5 increased the in vitro cytotoxicity of daunorubicin (DNR), adriamycin (ADM) and AsO in three hematologic tumor cell lines. In vivo studies showed that DNR combined with rhPDCD5 significantly suppressed tumor growth of U937 xenograft nude mice compared with DNR alone. In conclusion, rhPDCD5 combined with the chemotherapeutic drug has greater efficacy than chemotherapy alone, and rhPDCD5 is a very promising chemosensitizer. © 2009 Science in China Press and Springer Berlin Heidelberg.
KeywordApoptosis Chemosensitivity Chemotherapy Hematologic malignancies PDCD5
DOI10.1007/s11434-009-0635-z
URLView the original
Language英語
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Peking University
2.Peking University Health Science Center
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GB/T 7714
Wang Y.F.,Shi L.,Song Q.S.,et al. Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies[J]. Chinese Science Bulletin,2009,54(21):3981-3989.
APA Wang Y.F..,Shi L..,Song Q.S..,Zhang Y.M..,Lou Y.X..,...&Ke X.Y..(2009).Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies.Chinese Science Bulletin,54(21),3981-3989.
MLA Wang Y.F.,et al."Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies".Chinese Science Bulletin 54.21(2009):3981-3989.
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