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Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis
Wu, Xiaxia1; Guo, Yanling2; Min, Xiangjing2; Pei, Lixia3; Chen, Xiuping1,2
2018
Source PublicationAMERICAN JOURNAL OF CHINESE MEDICINE
ISSN0192-415X
Volume46Issue:6Pages:1263-1279
Abstract

Both the incidence and prevalence of ulcerative colitis (UC) are increasing throughout the world. Neferine, a natural alkaloid, demonstrated a variety of biological activities. In this study, the anti-inflammatory effect of neferine was investigated. Raw264.7 cells were stimulated with lipopolysaccharide (LPS) or LPS plus Z-VAD-fmk (Z-VAD). The inhibitory effect of neferine on secretion of nitrite, cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was determined. The protective effect of neferine was investigated in dextran sulfate sodium (DSS)-induced UC mouse model. Neferine significantly inhibited LPS and LPS plus Z-VAD induced secretion of nitrite, cytokines, and expression of iNOS and COX-2. Oral administration of neferine (10 mg/kg and 25 mg/kg) significantly reduced DSS-induced mouse weight loss, decreased disease activity index (DAI) scores, improved colon pathological changes, and decreased plasma cytokines. In addition, neferine significantly inhibited the protein expression of iNOS, COX-2, receptor-interacting protein 1 (RIP1), RIP3, mixed lineage kinase domain-like protein (MLKL), and increased the protein expression of caspase-8 in colon tissues. These data suggest that neferine was a potent anti-inflammatory agent against LPS and DSS induced inflammation both in vitro and in vivo.

KeywordNeferine Ulcerative Colitis Inflammation
DOIhttp://doi.org/10.1142/S0192415X18500660
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000446743100006
PublisherWORLD SCIENTIFIC PUBL CO PTE LTD
The Source to ArticleWOS
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, P. R. China
2.Key Lab for Pharmacology of Ministry of Education, Department of Pharmacology, Zunyi Medical College, Zunyi, P. R. China
3.Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wu, Xiaxia,Guo, Yanling,Min, Xiangjing,et al. Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2018,46(6):1263-1279.
APA Wu, Xiaxia,Guo, Yanling,Min, Xiangjing,Pei, Lixia,&Chen, Xiuping.(2018).Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis.AMERICAN JOURNAL OF CHINESE MEDICINE,46(6),1263-1279.
MLA Wu, Xiaxia,et al."Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis".AMERICAN JOURNAL OF CHINESE MEDICINE 46.6(2018):1263-1279.
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