UM
The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy
Wu X.1; Feng Q.-M.1; Wang Y.2; Shi J.1; Ge H.-L.2; Di W.1
2010-02-01
Source PublicationCancer Immunology, Immunotherapy
ISSN03407004 14320851
Volume59Issue:2Pages:279-291
AbstractTill now, little is known about the effects of chemotherapy on the immunity of cancer patients and the ideal timing ("window" period) for immunotherapy combined with chemotherapy. In this study, we addressed the immunogenicity of apoptotic ovarian cancer cells induced by paclitaxel and carboplatin, the immunologic aspects in ovarian cancer patients under chemotherapy, and the CTL response when CD8 T cells were stimulated with tumor antigen in the "window" period. The immunogenicity of apoptotic ovarian cancer cells was detected first. Then, blood samples from each ovarian cancer patient were obtained before (S) and at days 5-7 (S), days 12-14 (S) and days 25-28 (S) after chemotherapy. The proportions of immunocyte subsets and the function of NK cells were studied. We found that apoptotic ovarian cancer cells elicited a powerful CTL response with antitumor activity in vitro. The proportions of CD3 T cells, CD4 T cells and the ratio of CD4 to CD8 cells did not change significantly on S , S and S, compared to S, whereas the percentage of Treg cells decreased remarkably on S. The proportions of Th1, Tc1, CD45RO memory T, NKT cells and the ratio of Tc1 to Tc2 cells increased significantly on S. IFN-γ secreting CD8 T cells also increased remarkably on S, especially when CD8 T cells were stimulated with autologous tumor antigen. From our point of view, chemotherapy induces temporary immune reconstitution and augments anti-tumor immune response. It is probable that the "window" period of days 12-14 after chemotherapy provides the best opportunity for immunotherapy. © 2009 Springer-Verlag.
KeywordApoptosis Chemotherapy Immune reconstitution Immunogenicity Ovarian cancer
DOI10.1007/s00262-009-0749-9
URLView the original
Language英語
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Cited Times [WOS]:31   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Renji Hospital
2.Shanghai Jiao Tong University
Recommended Citation
GB/T 7714
Wu X.,Feng Q.-M.,Wang Y.,et al. The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy[J]. Cancer Immunology, Immunotherapy,2010,59(2):279-291.
APA Wu X.,Feng Q.-M.,Wang Y.,Shi J.,Ge H.-L.,&Di W..(2010).The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy.Cancer Immunology, Immunotherapy,59(2),279-291.
MLA Wu X.,et al."The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy".Cancer Immunology, Immunotherapy 59.2(2010):279-291.
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