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Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo
Chen C.; Zhou H.; Xu L.; Xu D.; Wang Y.; Zhang Y.; Liu X.; Liu Z.; Ma D.; Ma Q.; Chen Y.
2010-07-01
Source PublicationApoptosis
ISSN13608185 1573675X
Volume15Issue:7Pages:805-813
AbstractClinical management of chondrosarcoma remains a challenging problem, largely due to the toxicity and resistance of this tumor to conventional chemotherapy. Programmed Cell Death 5 (PDCD5) is a protein that accelerates apoptosis in different cell types in response to various stimuli, and has been shown to be down-regulated in many cancer tissues. In this study, mRNA and protein levels of PDCD5 were found to be up-regulated in cisplatintreated SW1353 chondrosarcoma cells compared with untreated cells. Recombinant human PDCD5 (rhPDCD5) was also shown to sensitize chondrosarcoma cells to cisplatin-based chemotherapy, with inhibition of cell growth and apoptosis detected both in vitro and in vivo. Increased expression of Bax and decreased expression of Bcl-2 were also observed, along with release of cytochrome c from mitochondria into the cytosol. Additionally, cleavage of caspase-9 and caspase-3, as well as the cleavage of poly (ADP-ribose) polymerase (PARP), were detected, suggesting that sensitization of chondrosarcoma cells involves the intrinsic mitochondrial apoptosis pathway. In vivo, the treatment of a xenograft model of chondrosarcoma with rhPDCD5 and cisplatin significantly inhibited tumor cell proliferation and induced apoptosis compared to treatment with cisplatin alone. Overall, these data provide a theoretical basis for the administration of rhPDCD5 and cisplatin for the treatment of patients with chondrosarcoma. © 2010 Springer Science+Business Media, LLC.
KeywordAntitumor activity Apoptosis Chondrosarcoma Cisplatin PDCD5
DOI10.1007/s10495-010-0489-5
URLView the original
Language英語
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被引频次[WOS]:40   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题University of Macau
AffiliationPeking University
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GB/T 7714
Chen C.,Zhou H.,Xu L.,et al. Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo[J]. Apoptosis,2010,15(7):805-813.
APA Chen C..,Zhou H..,Xu L..,Xu D..,Wang Y..,...&Chen Y..(2010).Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo.Apoptosis,15(7),805-813.
MLA Chen C.,et al."Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo".Apoptosis 15.7(2010):805-813.
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