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Protective effect of recombinant hepatical stimulator analogue on concanavalina A-induced acute liver injury in mice
Zhang X.-Y.; Hang Y.-F.; Wang J.; Ding X.-S.; Wang Y.; Ye B.-P.
2011-08-01
Source PublicationJournal of China Pharmaceutical University
ISSN10005048
Volume42Issue:4Pages:375-379
AbstractTo study the effect of recombinant shark hepatical stimulator analogue (r-sHSA) on Con A-induced acute liver injury in mice, serum aminotransferase activities and histological changes of hepatocytes were measured to assess the protective effect of r-sHSA (30, 60, 120 μg/kg). Hepatic malondialdehyde (MDA), glutathione (GSH) and total antioxidative capacity (T-AOC) levels, serum TNF-α and IFN-γ levels, and the activity of iNOS in hepatic homogenates were measured, respectively. Within all the three treated dosages, r-sHSA exhibited significant hepatoprotective effect by decreasing mouse serum aminotransferase activities, ameliorating hepatocyte necrosis and reducing inflammatory cell infiltration. The protection mechanism might be related with the reduced hepatic oxidative stress and proinflammatory cytokine production by r-sHSA pretreatment. These results indicated that r-sHSA could protect mice from Con A-induced acute liver injury through its antioxidant and anti-inflammatory activities.
KeywordAcute liver injury Anti-inflammation Concanavalina A Protection Recombinant shark hepatical stimulator analogue (r-sHSA)
URLView the original
Language英語
Fulltext Access
Document TypeJournal article
CollectionUniversity of Macau
AffiliationChina Pharmaceutical University
Recommended Citation
GB/T 7714
Zhang X.-Y.,Hang Y.-F.,Wang J.,et al. Protective effect of recombinant hepatical stimulator analogue on concanavalina A-induced acute liver injury in mice[J]. Journal of China Pharmaceutical University,2011,42(4):375-379.
APA Zhang X.-Y.,Hang Y.-F.,Wang J.,Ding X.-S.,Wang Y.,&Ye B.-P..(2011).Protective effect of recombinant hepatical stimulator analogue on concanavalina A-induced acute liver injury in mice.Journal of China Pharmaceutical University,42(4),375-379.
MLA Zhang X.-Y.,et al."Protective effect of recombinant hepatical stimulator analogue on concanavalina A-induced acute liver injury in mice".Journal of China Pharmaceutical University 42.4(2011):375-379.
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