UM
Genome-wide analysis of alternative splicing in Caenorhabditis elegans
Ramani A.K.1; Calarco J.A.1; Pan Q.1; Mavandadi S.1; Wang Y.2; Nelson A.C.3; Lee L.J.1; Morris Q.1; Blencowe B.J.1; Zhen M.1; Fraser A.G.1
2011-02-01
Source PublicationGenome Research
ISSN10889051 15495469
Volume21Issue:2Pages:342-348
AbstractAlternative splicing (AS) plays a crucial role in the diversification of gene function and regulation. Consequently, the systematic identification and characterization of temporally regulated splice variants is of critical importance to understanding animal development. We have used high-throughput RNA sequencing and microarray profiling to analyze AS in C. elegans across various stages of development. This analysis identified thousands of novel splicing events, including hundreds of developmentally regulated AS events. To make these data easily accessible and informative, we constructed the C. elegans Splice Browser, a web resource in which researchers can mine AS events of interest and retrieve information about their relative levels and regulation across development. The data presented in this study, along with the Splice Browser, provide the most comprehensive set of annotated splice variants in C. elegans to date, and are therefore expected to facilitate focused, high resolution in vivo functional assays of AS function. © 2011 by Cold Spring Harbor Laboratory Press.
DOI10.1101/gr.114645.110
URLView the original
Language英語
Fulltext Access
Citation statistics
Cited Times [WOS]:87   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.University of Toronto
2.The Lunenfeld-Tanenbaum Research Institute of University of Toronto
3.University of Cambridge
Recommended Citation
GB/T 7714
Ramani A.K.,Calarco J.A.,Pan Q.,et al. Genome-wide analysis of alternative splicing in Caenorhabditis elegans[J]. Genome Research,2011,21(2):342-348.
APA Ramani A.K..,Calarco J.A..,Pan Q..,Mavandadi S..,Wang Y..,...&Fraser A.G..(2011).Genome-wide analysis of alternative splicing in Caenorhabditis elegans.Genome Research,21(2),342-348.
MLA Ramani A.K.,et al."Genome-wide analysis of alternative splicing in Caenorhabditis elegans".Genome Research 21.2(2011):342-348.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ramani A.K.]'s Articles
[Calarco J.A.]'s Articles
[Pan Q.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ramani A.K.]'s Articles
[Calarco J.A.]'s Articles
[Pan Q.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ramani A.K.]'s Articles
[Calarco J.A.]'s Articles
[Pan Q.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.