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Intestinal permeability of the constituents from the roots of saposhnikovia divaricata in the human caco-2 cell monolayer model
Zhao B.2; Yang X.-B.1; Yang X.-W.4; Wu Q.4; Wang Y.4; Zhang L.-X.2; Xu W.4
2011-02-10
Source PublicationPlanta Medica
ISSN00320943 14390221
Volume77Issue:13Pages:1531-1535
AbstractThe bidirectional intestinal permeability of the active constituents from the roots of Saposhnikovia divaricata, including four coumarins, anomalin (1), 5-methoxy-7-(3,3-dimethylallyloxy)coumarin (2), decursin (3), and decursinol angelate (4), as well as four chromones, cimifugin (5), prim-O-glucosylcimifugin (6), 3-O-angeloylhamaudol (7), and sec-O-glucosylhamaudol (8), was studied by using the Caco-2 cell monolayer. These compounds were assayed by HPLC, and their transport parameters, including apparent permeability coefficients (P<), were then calculated. The bidirectional P values of the compounds were compared with those of the markers, propranolol and atenolol. Compounds 15 and 7 were assigned to well-absorbed compounds, while 6 and 8 were assigned to moderately absorbed compounds. The transport of 17 increased linearly as a function of time up to 180min and concentration within the test range of 10200M, thus their passive diffusion mechanism was proposed. The results provided some useful information for predicting the intestinal absorption in vivo of these compounds. © Georg Thieme Verlag KG Stuttgart New York.
KeywordCaco2 cell monolayer chromones coumarins Saposhnikovia divaricata Umbelliferae
DOI10.1055/s-0030-1270741
URLView the original
Language英語
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Xiyuan Hospital
2.Jilin Agricultural University
3.Beijing University of Chinese Medicine
4.Peking University
Recommended Citation
GB/T 7714
Zhao B.,Yang X.-B.,Yang X.-W.,et al. Intestinal permeability of the constituents from the roots of saposhnikovia divaricata in the human caco-2 cell monolayer model[J]. Planta Medica,2011,77(13):1531-1535.
APA Zhao B..,Yang X.-B..,Yang X.-W..,Wu Q..,Wang Y..,...&Xu W..(2011).Intestinal permeability of the constituents from the roots of saposhnikovia divaricata in the human caco-2 cell monolayer model.Planta Medica,77(13),1531-1535.
MLA Zhao B.,et al."Intestinal permeability of the constituents from the roots of saposhnikovia divaricata in the human caco-2 cell monolayer model".Planta Medica 77.13(2011):1531-1535.
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