UM
HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects naïve to antiretroviral therapy
Xiao J.2; Qian K.-L.1; Cao Q.-H.1; Qiu C.-L.3; Qiu C.3; Xue Y.-L.1; Zhang X.-Y.3; Zhong P.1; Xu J.-Q.3; Li M.-Y.2; Wang Y.1
2011-08-05
Source PublicationChinese Medical Journal
ISSN03666999
Volume124Issue:15Pages:2340-2346
AbstractBackground The frequencies of regulatory T cells (Tregs) increased over the HIV infection but its counts actually decreased. We proposed that the decrease of Treg counts may cause the reduction of inhibitory effect and thereby account for the over-activation of Tregs during HIV infection. However, it remains unknown whether Tregs are also over-activated and thereafter the activation induced death may lead to the decrease of Tregs. Methods Tregs were defined as CD4 CD25 CD127 T cells. Eighty-one HIV-1 infected patients were enrolled in our study, and twenty-two HIV-1 seronegative donors were recruited as the control. The levels of HLA-DR on Tregs were determined by FACSAria flow cytometer. Results Compared to HIV-1 seronegative donors, the levels of HLA-DR on CD4 CD25 CD127 Tregs were significantly increased in HIV-1 infected patients, and its increase was positively associated with viral loads (r=0.3163, P=0.004) and negatively with CD4 T-cell counts (r=-0.4153, P <0.0001). In addition, significant associations between HLA-DR expression on CD4 CD25 CD127 Tregs and the percentages of HLA-DR, CD38, Ki67 expressing CD4 and CD8 T cells were also identified. Conclusion HLA-DR on Tregs is a good marker for viral replication and disease progression. The over-activation of Tregs might result in the decrease of Tregs.
KeywordHLA-DR antigens Human immunodeficiency virus type 1 Immune activation Regulatory T-lymphocytes
DOI10.3760/cma.j.issn.0366-6999.2011.15.017
URLView the original
Language英語
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Municipal Center for Disease Control and Prevention
2.Sichuan University
3.Fudan University Shanghai Medical College
Recommended Citation
GB/T 7714
Xiao J.,Qian K.-L.,Cao Q.-H.,et al. HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects naïve to antiretroviral therapy[J]. Chinese Medical Journal,2011,124(15):2340-2346.
APA Xiao J..,Qian K.-L..,Cao Q.-H..,Qiu C.-L..,Qiu C..,...&Wang Y..(2011).HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects naïve to antiretroviral therapy.Chinese Medical Journal,124(15),2340-2346.
MLA Xiao J.,et al."HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects naïve to antiretroviral therapy".Chinese Medical Journal 124.15(2011):2340-2346.
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