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Cognate Th2-B cell interaction is essential for the autoantibody production in pemphigus vulgaris
Zhu H.; Chen Y.; Zhou Y.; Wang Y.; Zheng J.; Pan M.
2012-02-01
Source PublicationJournal of Clinical Immunology
ISSN02719142 15732592
Volume32Issue:1Pages:114-123
AbstractPemphigus vulgaris (PV) is a Th2-dominant autoimmune skin disease. We showed that indeed active PV patients had a biased Th2 response and specific IgG4 autoantibodies were dominant. To further investigate the role of antigen-specific Th2 cells in the regulation of pathogenic Dsg3-IgG antibody production, we used recombined Dsg3 protein to immunize wildtype C57BL/6 mice with aluminum hydroxide or complete Freund's adjuvant as adjuvant. CD4 T cells from Dsg3-immunized mice were adoptively transferred into TCR-β chain deficient mice. The transferred CD4 T cells were readily seen in the peripheral blood and spleen, and interacted with B cells, resulting in B-cell activation. Furthermore, transferred CD4 T cells from mice immunized with Dsg3 plus Alum with Th2 phenotype were able to render unprimed B cells to secrete Dsg3-specific IgG1 antibody in vivo. Taken together, these results provide the first demonstration of direct role of Dsg3-reactive CD4 T (Th2) cells in the regulation of pathologic anti-Dsg3 antibody production. © Springer Science+Business Media, LLC 2011.
KeywordDsg3 Igg4 subclass Pemphigus vulgaris Th2 cell
DOI10.1007/s10875-011-9597-4
URLView the original
Language英語
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationShanghai Jiao Tong University
Recommended Citation
GB/T 7714
Zhu H.,Chen Y.,Zhou Y.,et al. Cognate Th2-B cell interaction is essential for the autoantibody production in pemphigus vulgaris[J]. Journal of Clinical Immunology,2012,32(1):114-123.
APA Zhu H.,Chen Y.,Zhou Y.,Wang Y.,Zheng J.,&Pan M..(2012).Cognate Th2-B cell interaction is essential for the autoantibody production in pemphigus vulgaris.Journal of Clinical Immunology,32(1),114-123.
MLA Zhu H.,et al."Cognate Th2-B cell interaction is essential for the autoantibody production in pemphigus vulgaris".Journal of Clinical Immunology 32.1(2012):114-123.
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