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A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles
Mert O.1; Lai S.K.1; Ensign L.1; Yang M.1; Wang Y.-Y.1; Wood J.1; Hanes J.1
2012-02-10
Source PublicationJournal of Controlled Release
ISSN01683659 18734995
Volume157Issue:3Pages:455-460
AbstractMucosal surfaces are protected by a highly viscoelastic and adhesive mucus layer that traps most foreign particles, including conventional drug and gene carriers. Trapped particles are eliminated on the order of seconds to hours by mucus clearance mechanisms, precluding sustained and targeted drug and nucleic acid delivery to mucosal tissues. We have previously shown that polymeric coatings that minimize adhesive interactions with mucus constituents lead to particles that rapidly penetrate human mucus secretions. Nevertheless, a particular challenge in formulating drug-loaded mucus penetrating particles (MPP) is that many commonly used surfactants are either mucoadhesive, or do not facilitate efficient drug encapsulation. We tested a novel surfactant molecule for particle formulation composed of Vitamin E conjugated to 5 kDa poly(ethylene glycol) (VP5k). We show that VP5k-coated poly(lactide-co-glycolide) (PLGA) nanoparticles rapidly penetrate human cervicovaginal mucus, whereas PLGA nanoparticles coated with polyvinyl alcohol or Vitamin E conjugated to 1 kDa PEG were trapped. Importantly, VP5k facilitated high loading of paclitaxel, a frontline chemo drug, into PLGA MPP, with controlled release for at least 4 days and negligible burst release. Our results offer a promising new method for engineering biodegradable, drug-loaded MPP for sustained and targeted delivery of therapeutics at mucosal surfaces. © 2011 Elsevier B.V. All rights reserved.
KeywordDrug delivery Mucin PEG Vitamin E TPGS
DOI10.1016/j.jconrel.2011.08.032
URLView the original
Language英語
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Cited Times [WOS]:61   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Johns Hopkins University
2.The University of North Carolina at Chapel Hill
3.The Wilmer Eye Institute at Johns Hopkins
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Mert O.,Lai S.K.,Ensign L.,et al. A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles[J]. Journal of Controlled Release,2012,157(3):455-460.
APA Mert O..,Lai S.K..,Ensign L..,Yang M..,Wang Y.-Y..,...&Hanes J..(2012).A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles.Journal of Controlled Release,157(3),455-460.
MLA Mert O.,et al."A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles".Journal of Controlled Release 157.3(2012):455-460.
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