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The effects of erythropoietin dose titration during high-fat diet-induced obesity
Noguchi C.T.; Foskett A.; Alnaeeli M.; Wang L.; Teng R.
2011-06-24
Source PublicationJournal of Biomedicine and Biotechnology
ISSN11107243 11107251
Volume2011
Abstract

Erythropoietin (Epo) is a pleotropic cytokine with several nonhematopoietic tissue effects. High-dose Epo treatment-mediated effects on body weight, fat mass and glucose tolerance have recently been reported, thus extending its pleotropic effects to fat and glucose metabolism. However, the exact dose range of Epo treatment required for such effects remains unidentified to date. We investigated Epo dosage effect (up to 1000U/kg) on hematocrit, body weight, body composition, glucose metabolism, food intake, and physical activity, during high-fat diet-induced obesity. We report that Epo doses (1000, 600, 300, and 150U/kg) significantly reduced body weight gain and fat mass, while, only Epo doses of 300U/kg and higher significantly affected glucose tolerance. None of the tested Epo doses showed any detectable effects on food intake, and only 1000U/kg dose significantly increased physical activity, suggesting that these parameters may only be partially responsible for the metabolic effects of Epo treatment. Copyright 2011 Amanda Foskett et al.

DOI10.1155/2011/373781
URLView the original
Indexed BySCI
WOS Research AreaBiotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS SubjectBiotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS IDWOS:000298439100001
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationNational Institute of Diabetes and Digestive and Kidney Diseases
Recommended Citation
GB/T 7714
Noguchi C.T.,Foskett A.,Alnaeeli M.,et al. The effects of erythropoietin dose titration during high-fat diet-induced obesity[J]. Journal of Biomedicine and Biotechnology,2011,2011.
APA Noguchi C.T.,Foskett A.,Alnaeeli M.,Wang L.,&Teng R..(2011).The effects of erythropoietin dose titration during high-fat diet-induced obesity.Journal of Biomedicine and Biotechnology,2011.
MLA Noguchi C.T.,et al."The effects of erythropoietin dose titration during high-fat diet-induced obesity".Journal of Biomedicine and Biotechnology 2011(2011).
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