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T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis
Rogers H.1; Wang L.1; Yu X.1; Alnaeeli M.1; Cui K.7; Zhao K.7; Bieker J.J.5; Prchal J.6; Huang S.4; Weksler B.2; Noguchi C.T.1
2012-10-26
Source PublicationJournal of Biological Chemistry
ISSN00219258 1083351X
Volume287Issue:44Pages:36720-36731
Abstract

Background: Erythropoietin is required for erythrocyte production and stimulates erythroid gene expression including EPO-R. Results: TAL1 induction promotes accessibility of EPO-R promoter to the GATA-1-TAL1-LMO2-LDB1 transcription activation complex to increase EPO-R expression. Conclusion: Forced TAL1 expression increases EPO-R and erythropoietin hypersensitivity in erythroid progenitors. Significance: Providing insight into the molecular link between TAL1 and erythropoietin activity.

DOI10.1074/jbc.M112.378398
URLView the original
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000310588500010
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.NIDDK
2.Weill Cornell Medical College
3.University of California, San Francisco
4.University of Florida College of Medicine
5.Icahn School of Medicine at Mount Sinai
6.University of Utah
7.National Heart, Lung, and Blood Institute
Recommended Citation
GB/T 7714
Rogers H.,Wang L.,Yu X.,et al. T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis[J]. Journal of Biological Chemistry,2012,287(44):36720-36731.
APA Rogers H..,Wang L..,Yu X..,Alnaeeli M..,Cui K..,...&Noguchi C.T..(2012).T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.Journal of Biological Chemistry,287(44),36720-36731.
MLA Rogers H.,et al."T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis".Journal of Biological Chemistry 287.44(2012):36720-36731.
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