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The efficacy of Guanxinning injection in treating angina pectoris: systematic review and meta-analysis of randomized controlled trials
Yongliang Jia1; Siu-wai Leung1,2; Ming-Yuen Lee1; Guozhen Cui1; Xiaohui Huang1; Fongha Pan1
2013
Source PublicationEvidence-Based Complementary and Alternative Medicine
ISSN1741-4288
Volume2013Pages:1-16
Abstract

Objective. The randomized controlled trials (RCTs) on Guanxinning injection (GXN) in treating angina pectoris were published
only in Chinese and have not been systematically reviewed. This study aims to provide a PRISMA-compliant and internationally
accessible systematic review to evaluate the efficacy of GXN in treating angina pectoris. Methods. The RCTs were included
according to prespecified eligibility criteria. Meta-analysis was performed to evaluate the symptomatic (SYMPTOMS) and
electrocardiographic (ECG) improvements after treatment.Odds ratios (ORs) were used to measure effect sizes. Subgroup analysis,
sensitivity analysis, and metaregression were conducted to evaluate the robustness of the results. Results. Sixty-five RCTs published
between 2002 and 2012 with 6064 participants were included. Overall ORs comparing GXN with other drugs were 3.32 (95% CI:
[2.72, 4.04]) in SYMPTOMS and 2.59 (95% CI: [2.14, 3.15]) in ECG. Subgroup analysis, sensitivity analysis, and metaregression
found no statistically significant dependence of overall ORs upon specific study characteristics. Conclusion.This meta-analysis of
eligible RCTs provides evidence that GXN is effective in treating angina pectoris. This evidence warrants further RCTs of higher
quality, longer follow-up periods, larger sample sizes, andmulticentres/multicountries for more extensive subgroup, sensitivity, and
metaregression analyses.

DOIhttps://doi.org/10.1155/2013/282707
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000317207800001
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSiu-wai Leung
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
2.School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yongliang Jia,Siu-wai Leung,Ming-Yuen Lee,et al. The efficacy of Guanxinning injection in treating angina pectoris: systematic review and meta-analysis of randomized controlled trials[J]. Evidence-Based Complementary and Alternative Medicine,2013,2013:1-16.
APA Yongliang Jia,Siu-wai Leung,Ming-Yuen Lee,Guozhen Cui,Xiaohui Huang,&Fongha Pan.(2013).The efficacy of Guanxinning injection in treating angina pectoris: systematic review and meta-analysis of randomized controlled trials.Evidence-Based Complementary and Alternative Medicine,2013,1-16.
MLA Yongliang Jia,et al."The efficacy of Guanxinning injection in treating angina pectoris: systematic review and meta-analysis of randomized controlled trials".Evidence-Based Complementary and Alternative Medicine 2013(2013):1-16.
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