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Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice
Zhu J.1; Chen Q.1; Xia X.1; Mo P.1; Shen Y.2; Yu C.1
2013
Source PublicationApplied Microbiology and Biotechnology
ISSN01757598 14320614
Volume97Issue:2Pages:767-774
Abstract

Mycoepoxydiene (MED) is a compound isolated from the marine fungal Diaporthe sp. HLY-1 associated with mangroves. MED has various biological effects such as anti-microbial, anti-cancer, and anti-inflammatory activities. However, the effect of MED on the differentiation of osteoclasts, the multinucleated bone-resorbing cells which play a crucial role in bone remodeling, is still unknown. In this study, we showed that MED could inhibit receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation and the expression of three well-known osteoclast markers such as tartrate-resistant acid phosphatase, calcitonin receptor, and cathepsin K in bone marrow-derived macrophages. Furthermore, we found that MED inhibited the expression of nuclear factor of activated T cells c1, a key transcriptional factor in osteoclast differentiation, via inhibiting the phosphorylation of TAK1 and then blocking the activation of NF-κB and ERK1/2 pathways. Moreover, MED could prevent bone loss in ovariectomized mice. Taken together, we demonstrate for the first time that MED can suppress RANKL-induced osteoclast differentiation in vitro and ovariectomy-induced osteoporosis in vivo, suggesting that MED is a potential lead compound for the development of novel drugs for osteoporosis treatment. © 2012 Springer-Verlag.

KeywordErk1/2 Mycoepoxydiene Nf-kb Nfatc1 Osteoclast Differentiation
DOI10.1007/s00253-012-4146-5
URLView the original
Indexed BySCI
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000313651700027
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Xiamen University
2.Shandong University
Recommended Citation
GB/T 7714
Zhu J.,Chen Q.,Xia X.,et al. Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice[J]. Applied Microbiology and Biotechnology,2013,97(2):767-774.
APA Zhu J.,Chen Q.,Xia X.,Mo P.,Shen Y.,&Yu C..(2013).Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice.Applied Microbiology and Biotechnology,97(2),767-774.
MLA Zhu J.,et al."Mycoepoxydiene suppresses RANKL-induced osteoclast differentiation and reduces ovariectomy-induced bone loss in mice".Applied Microbiology and Biotechnology 97.2(2013):767-774.
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