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Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles
Sun, Lin1,2; Liu, Zeyu1; Lin, Zibei1; Cun, Dongmei3; Tong, Henry H. Y.4; Yan, Ru1; Wang, Ruibing1; Zheng, Ying1
2018
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
Volume13Pages:5625-5635
Abstract

Background: As an immune-mediated skin disease, psoriasis encounters therapeutic challenges on topical drug development due to the unclear mechanism, and complicated morphological and physiological changes in the skin.
Methods: In this study, imiquimod-induced psoriatic mouse skin (IMQ-psoriatic skin) was chosen as the in vitro pathological model to explore the penetration behaviors of drugs and nanoparticles (NPs).
Results: Compared with normal skin, significantly higher penetration and skin accumulation were observed in IMQ-psoriatic skin for all the three model drugs. When poorly water-soluble curcumin was formulated as NPs that were subsequently loaded in gel, the drug’s penetration and accumulation in both normal and IMQ-psoriatic skins were significantly improved, in comparison with that of the curcumin suspension. Interestingly, the NPs’ size effect, in terms of their penetration and accumulation behaviors, was more pronounced for IMQ-psoriatic skin. Furthermore, by taking three sized FluoSpheres® as model NPs, confocal laser scanning microscopy demonstrated that the penetration pathways of NPs no longer followed the hair follicles channels, instead they were more widely distributed in the IMQ-psoriatic skin.
Conclusion: In conclusion, the alternation of the IMQ-psoriatic skin structure will lead to the enhanced penetration of drug and NPs, and should be considered in topical drug formulation and further clinical practice for psoriasis therapy.

KeywordImiquimod-induced Psoriatic Skin Pathological Model Topical Delivery Penetration Nanoparticles
DOIhttps://doi.org/10.2147/IJN.S170832
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000445523800001
PublisherDOVE MEDICAL PRESS LTD
The Source to ArticleWOS
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZheng, Ying
Affiliation1.State Key laboratory of Quality research in chinese Medicine, Institute of chinese Medical sciences, University of Macau, Macao special administrative region, People’s republic of china
2.Department of Pharmaceutical sciences, Zhuhai campus of Zunyi Medical University, Zhuhai, guangdong, 519041, People’s republic of china
3.Department of Pharmaceutical sciences, shenyang Pharmaceutical University, shenyang, liaoning, 110016, People’s republic of china
4.School of health sciences, Macao Polytechnic Institute, Macao special administrative region, People’s republic of china
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Sun, Lin,Liu, Zeyu,Lin, Zibei,et al. Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:5625-5635.
APA Sun, Lin.,Liu, Zeyu.,Lin, Zibei.,Cun, Dongmei.,Tong, Henry H. Y..,...&Zheng, Ying.(2018).Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles.INTERNATIONAL JOURNAL OF NANOMEDICINE,13,5625-5635.
MLA Sun, Lin,et al."Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles".INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):5625-5635.
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