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A pH responsive fluorescent probe based on dye modified i-motif nucleic acids
Li P.3; Chen Z.3; Huang Y.3; Li J.3; Xiao F.3; Zhai S.3; Wang Z.1; Zhang X.2; Tian L.3
2018
Source PublicationOrganic and Biomolecular Chemistry
ISSN14770520
Volume16Issue:48Pages:9402-9408
Abstract

A new DNA-based fluorescent probe, which is a hybrid molecule of an i-motif forming sequence (IFS) and mono-functionalized tetraphenylethene (TPE), has been synthesized and investigated. A distinct pH-responsive aggregation-induced emission (AIE) effect has been observed from this hybrid molecule, i.e. the fluorescence of TPE will be turned on when the IFS part folds up under acidic conditions. According to the fact that a hybrid molecule with a relatively rigid structure shows a more obvious AIE effect, and whose nano-sized aggregates are formed at a high concentration, we assume that the solubility of the hybrid molecule in water will be reduced due to IFS folding, resulting in aggregation and the resultant AIE effect. Finally, due to its excellent pH responsiveness, this DNA-based probe employing an AIEgen has been applied in monitoring intracellular pH.

DOI10.1039/c8ob02885k
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000453230000012
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Citation statistics
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Hong Kong University of Science and Technology, Shenzhen Research Institute
2.Universidade de Macau
3.Southern University of Science and Technology
Recommended Citation
GB/T 7714
Li P.,Chen Z.,Huang Y.,et al. A pH responsive fluorescent probe based on dye modified i-motif nucleic acids[J]. Organic and Biomolecular Chemistry,2018,16(48):9402-9408.
APA Li P..,Chen Z..,Huang Y..,Li J..,Xiao F..,...&Tian L..(2018).A pH responsive fluorescent probe based on dye modified i-motif nucleic acids.Organic and Biomolecular Chemistry,16(48),9402-9408.
MLA Li P.,et al."A pH responsive fluorescent probe based on dye modified i-motif nucleic acids".Organic and Biomolecular Chemistry 16.48(2018):9402-9408.
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