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Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate
Sarah J. Hemauer1; Ru Yan1; Svetlana L. Patrikeeva1; Donald R. Mattison2; Gary D. V. Hankins1; Mahmoud S. Ahmed1; Tatiana N. Nanovskaya1
2008-08
Source PublicationAmerican Journal of Obstetrics and Gynecology
ISSN0002-9378
Volume199Issue:2Pages:169.e1-169.e5
Abstract

 

Other Abstract

Objective

Determine transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate and its distribution between the tissue and the maternal and fetal circuits of the dually perfused placental lobule.

Study Design

17-α-Hydroxyprogesterone caproate (21 ng/mL) and its dual-labeled isotope, 17-α-hydroxy-[3H] progesterone [14C] caproate were added to the maternal circuit. The concentrations of the drug and its metabolite in trophoblast tissue and both circuits were determined by high performance liquid chromatography and liquid scintillation spectrometry.

Results

17-α-Hydroxyprogesterone caproate was transferred from the maternal to fetal circuit. After a 4-hour perfusion period, a metabolite of 17-α-hydroxyprogesterone caproate that retained both progesterone and caproate moieties was identified in the tissue and the maternal and fetal circuits. Neither 17-α-hydroxyprogesterone caproate nor its metabolite, at the concentrations tested, had adverse effect on determined viability and functional parameters of placental tissue.

Conclusion

17-α-Hydroxyprogesterone caproate was metabolized by term placental lobule during its perfusion and both parent compound and its metabolite(s) transferred to the fetal circuit.

KeywordDual Perfusion Metabolism Preterm Delivery 17-α-hydroxyprogesterone Caproate
DOIhttps://doi.org/10.1016/j.ajog.2007.11.065
Indexed BySCI
Language英语
WOS Research AreaObstetrics & Gynecology
WOS SubjectObstetrics & Gynecology
WOS IDWOS:000258031500031
PublisherMOSBY-ELSEVIER, 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
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被引频次[WOS]:17   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Affiliation1.Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX
2.Obstetric-Fetal Pharmacology Research Unit (OPRU) Network, Center for Research for Mothers & Children, National Institute of Child Health and Human Development, Bethesda, MD.
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Sarah J. Hemauer,Ru Yan,Svetlana L. Patrikeeva,et al. Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate[J]. American Journal of Obstetrics and Gynecology,2008,199(2):169.e1-169.e5.
APA Sarah J. Hemauer.,Ru Yan.,Svetlana L. Patrikeeva.,Donald R. Mattison.,Gary D. V. Hankins.,...&Tatiana N. Nanovskaya.(2008).Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate.American Journal of Obstetrics and Gynecology,199(2),169.e1-169.e5.
MLA Sarah J. Hemauer,et al."Transplacental transfer and metabolism of 17-α-hydroxyprogesterone caproate".American Journal of Obstetrics and Gynecology 199.2(2008):169.e1-169.e5.
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