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表达蛋白质组学在抗肿瘤药物研发中的应用
陆金健1,2,3; 黄鸣清1,2,4; 陈修平1,2; 王一涛1,2
2012
Source Publication中国新药杂志
ISSN1003-3734
Volume21Issue:1Pages:43-47
Abstract

表达蛋白质组学主要对正常、疾病或药物处理细胞或亚细胞中的所有蛋白质进行定性或定量
研究。近年来表达蛋白质组学对抗肿瘤药物的研发起到了一定的推动作用。本文通过检索相关数据库文
献,对其进行梳理、总结和归纳,阐述了表达蛋白质组学在抗肿瘤药物研发中的应用,包括抗肿瘤药物靶点发
现、药物作用机制阐明、临床诊断以及基于网络药理学的药物研发理念的实现等。尽管表达蛋白质组学本身
还存在一些缺陷,但随着其技术的不断发展,必将进一步促进抗肿瘤创新药物的研发。

Other Abstract

The object of expression proteomics is to define and quantify all proteins within a cell or subcellular
organelle under normal,diseased or drug-treated conditions. In the recent years,expression proteomics
plays a role in the research and development of anti-cancer drugs. Herein,we referred and summarized the relevant
literature,and introduced the expression proteomics used for the research and development of anti-cancer drugs,including
discovery of new targets,clarification of action mechanisms of drugs,clinical diagnosis,and the realization
of drug development concept based on the network pharmacology. Although expression proteomics itself still has
some flaws,it has a broad prospect of application and will greatly promote the research and development of innovative
anti-cancer drugs.

Keyword表达蛋白质组学 抗肿瘤 药物研发 网络药理学
Language中文
Fulltext Access
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.澳门大学中药质量研究国家重点实验室,澳门999078
2.浙江中医药大学生命科学学院,杭州310053
3.福建中医药大学药学院,福州350108
4.澳门大学中华医药研究院,澳门999078
Recommended Citation
GB/T 7714
陆金健,黄鸣清,陈修平,等. 表达蛋白质组学在抗肿瘤药物研发中的应用[J]. 中国新药杂志,2012,21(1):43-47.
APA 陆金健,黄鸣清,陈修平,&王一涛.(2012).表达蛋白质组学在抗肿瘤药物研发中的应用.中国新药杂志,21(1),43-47.
MLA 陆金健,et al."表达蛋白质组学在抗肿瘤药物研发中的应用".中国新药杂志 21.1(2012):43-47.
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