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Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3
Ahmed M.; Cheng M.; Zhao Q.; Goldgur Y.; Cheal S.M.; Guo H.-F.; Larson S.M.; Cheung N.-K.V.
2015-12-11
Source PublicationJournal of Biological Chemistry
ISSN1083351X 00219258
Volume290Issue:50Pages:30018-30029
Abstract

Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3. Conclusion: hu8H9 antibodies had potent antitumor activity and may modulate immune inhibitory properties of B7-H3. Significance: Antibodies were developed to target solid tumors and affect immune checkpoint blockade.

DOI10.1074/jbc.M115.679852
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000366614700033
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationMemorial Sloan-Kettering Cancer Center
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GB/T 7714
Ahmed M.,Cheng M.,Zhao Q.,et al. Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3[J]. Journal of Biological Chemistry,2015,290(50):30018-30029.
APA Ahmed M..,Cheng M..,Zhao Q..,Goldgur Y..,Cheal S.M..,...&Cheung N.-K.V..(2015).Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3.Journal of Biological Chemistry,290(50),30018-30029.
MLA Ahmed M.,et al."Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3".Journal of Biological Chemistry 290.50(2015):30018-30029.
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