UM  > Institute of Chinese Medical Sciences
Stability of nanosuspensions in drug delivery
Yancai Wang1,2; Ying Zheng2; Ling Zhang3; Qiwei Wang4; Dianrui Zhang4
2013-12-28
Source PublicationJournal of Controlled Release
ISSN0168-3659
Volume172Issue:3Pages:1126-1141
Abstract

Nanosuspensions are nanosized colloidal dispersion systems that are stabilized by surfactants and/or polymers. Because nanosizing results in the creation of new interfaces and in a positive Gibbs free energy change, nanosuspensions are thermodynamically unstable systems with a tendency toward agglomeration or crystal growth. Despite extensive research on nanosuspension technology, stability remains a limitation for pharmaceutical or industrial applications of nanosuspensions. Furthermore, the empirical relationship between stabilizer efficacy and nanosuspension stability has not been well characterized. This review focuses on the issue of nanosuspension stability in drug delivery to present the state of the art of nanosuspensions. Therefore, this review will discuss unstable suspensions, methods and guidelines for selecting and optimizing stabilizers, approaches for enhancing stability, and other factors that influence nanosuspension stability. This review could serve as a reference for the educated selection of a stabilizer for a specific drug candidate and the optimization of the operational parameters for nanosuspension formulation, rather than the currently practiced trial-and-error approach.

KeywordNanosuspensions Stability Stabilizers Aggregation Crystalline Transformation
DOIhttps://doi.org/10.1016/j.jconrel.2013.08.006
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000328492800055
PublisherELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Fulltext Access
Citation statistics
Cited Times [WOS]:179   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYancai Wang
Affiliation1.School of Chemistry and Pharmaceutical Engineering, Shandong Polytechnic University, Jinan 250353, PR China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, PR China
3.Library, Shandong University of Finance and Economics, Jinan 250014, PR China
4.College of Pharmacy, Shandong University, Jinan 250012, PR China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yancai Wang,Ying Zheng,Ling Zhang,et al. Stability of nanosuspensions in drug delivery[J]. Journal of Controlled Release,2013,172(3):1126-1141.
APA Yancai Wang,Ying Zheng,Ling Zhang,Qiwei Wang,&Dianrui Zhang.(2013).Stability of nanosuspensions in drug delivery.Journal of Controlled Release,172(3),1126-1141.
MLA Yancai Wang,et al."Stability of nanosuspensions in drug delivery".Journal of Controlled Release 172.3(2013):1126-1141.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yancai Wang]'s Articles
[Ying Zheng]'s Articles
[Ling Zhang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yancai Wang]'s Articles
[Ying Zheng]'s Articles
[Ling Zhang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yancai Wang]'s Articles
[Ying Zheng]'s Articles
[Ling Zhang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.