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Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems
Jiang N.4; Tang L.1; Xie R.4; Li Z.4; Burkinshaw B.1; Liang X.5; Sosa D.2; Aravind L.3; Dong T.1; Zhang D.2; Zheng J.4
2018-12-01
Source PublicationNature Communications
ISSN20411723
Volume9Issue:1
AbstractType VI secretion systems (T6SSs) translocate effector proteins, such as Rhs toxins, to eukaryotic cells or prokaryotic competitors. All T6SS Rhs-type effectors characterized thus far contain a PAAR motif or a similar structure. Here, we describe a T6SS-dependent delivery mechanism for a subset of Rhs proteins that lack a PAAR motif. We show that the N-terminal Rhs domain of protein RhsP (or VP1517) from Vibrio parahaemolyticus inhibits the activity of the C-terminal DNase domain. Upon auto-proteolysis, the Rhs fragment remains inside the cells, and the C-terminal region interacts with PAAR2 and is secreted by T6SS2; therefore, RhsP acts as a pro-effector. Furthermore, we show that RhsP contributes to the control of certain “social cheaters” (opaR mutants). Genes encoding proteins with similar Rhs and PAAR-interacting domains, but diverse C-terminal regions, are widely distributed among Vibrio species.
DOI10.1038/s41467-018-06201-5
URLView the original
Language英語
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.University of Calgary
2.St. Louis University
3.National Library of Medicine
4.Universidade de Macau
5.Shanghai Jiao Tong University
Recommended Citation
GB/T 7714
Jiang N.,Tang L.,Xie R.,et al. Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems[J]. Nature Communications,2018,9(1).
APA Jiang N..,Tang L..,Xie R..,Li Z..,Burkinshaw B..,...&Zheng J..(2018).Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems.Nature Communications,9(1).
MLA Jiang N.,et al."Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems".Nature Communications 9.1(2018).
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