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Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems
Jiang N.4; Tang L.1; Xie R.4; Li Z.4; Burkinshaw B.1; Liang X.5; Sosa D.2; Aravind L.3; Dong T.1; Zhang D.2; Zheng J.4
2018-12-01
Source PublicationNature Communications
ISSN20411723
Volume9Issue:1
Abstract

Type VI secretion systems (T6SSs) translocate effector proteins, such as Rhs toxins, to eukaryotic cells or prokaryotic competitors. All T6SS Rhs-type effectors characterized thus far contain a PAAR motif or a similar structure. Here, we describe a T6SS-dependent delivery mechanism for a subset of Rhs proteins that lack a PAAR motif. We show that the N-terminal Rhs domain of protein RhsP (or VP1517) from Vibrio parahaemolyticus inhibits the activity of the C-terminal DNase domain. Upon auto-proteolysis, the Rhs fragment remains inside the cells, and the C-terminal region interacts with PAAR2 and is secreted by T6SS2; therefore, RhsP acts as a pro-effector. Furthermore, we show that RhsP contributes to the control of certain “social cheaters” (opaR mutants). Genes encoding proteins with similar Rhs and PAAR-interacting domains, but diverse C-terminal regions, are widely distributed among Vibrio species.

DOI10.1038/s41467-018-06201-5
URLView the original
Indexed BySCIE
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000445560800007
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionPersonal research not belonging to the institution
Faculty of Health Sciences
Affiliation1.University of Calgary
2.St. Louis University
3.National Library of Medicine
4.Universidade de Macau
5.Shanghai Jiao Tong University
Recommended Citation
GB/T 7714
Jiang N.,Tang L.,Xie R.,et al. Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems[J]. Nature Communications,2018,9(1).
APA Jiang N..,Tang L..,Xie R..,Li Z..,Burkinshaw B..,...&Zheng J..(2018).Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems.Nature Communications,9(1).
MLA Jiang N.,et al."Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems".Nature Communications 9.1(2018).
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