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Antagonistic actions of juvenile hormone and 20-hydroxyecdysone within the ring gland determine developmental transitions in Drosophila
Liu, Suning1,2,3; Li, Kang1,2,3; Gao, Yue1,2; Liu, Xi3; Chen, Weiting4; Ge, Wei4; Feng, Qili1,2; Palli, Subba R.5; Li, Sheng1,2,3
2018-01-02
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume115Issue:1Pages:139-144
Abstract

In both vertebrates and insects, developmental transition from the juvenile stage to adulthood is regulated by steroid hormones. In insects, the steroid hormone, 20-hydroxyecdysone (20E), elicits metamorphosis, thus promoting this transition, while the sesquiterpenoid juvenile hormone (JH) antagonizes 20E signaling to prevent precocious metamorphosis during the larval stages. However, not much is known about the mechanisms involved in crosstalk between these two hormones. In this study, we discovered that in the ring gland (RG) of Drosophila larvae, JH and 20E control each other's biosynthesis. JH induces expression of a Kruppel-like transcription factor gene Kr-h1 in the prothoracic gland (PG), a portion of the RG that produces the 20E precursor ecdysone. By reducing both steroidogenesis autoregulation and PG size, high levels of Krh1 in the PG inhibit ecdysteriod biosynthesis, thus maintaining juvenile status. JH biosynthesis is prevented by 20E in the corpus allatum, the other portion of the RG that produces JH, to ensure the occurrence of metamorphosis. Hence, antagonistic actions of JH and 20E within the RG determine developmental transitions in Drosophila. Our study proposes amechanism of cross-talk between the twomajor hormones in the regulation of insect metamorphosis.

KeywordJuvenile Hormone 20-hydroxyecdysone Ring Gland Hormone Biosynthesis Antagonistic Action
DOI10.1073/pnas.1716897115
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000419128700041
PublisherNATL ACAD SCIENCES
The Source to ArticleWOS
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Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Guangzhou Key Laboratory of Insect Development Regulation and Application Research, School of Life Sciences, South China Normal University, Guangzhou, 510631, China
2.Institute of Insect Science and Technology, South China Normal University, Guangzhou, 510631, China
3.Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China
4.Faculty of Health Science, University of Macau, Macau, 00853, China
5.Department of Entomology, College of Agriculture, Food, and Environment, University of Kentucky, Lexington, KY, 40546
Recommended Citation
GB/T 7714
Liu, Suning,Li, Kang,Gao, Yue,et al. Antagonistic actions of juvenile hormone and 20-hydroxyecdysone within the ring gland determine developmental transitions in Drosophila[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018,115(1):139-144.
APA Liu, Suning.,Li, Kang.,Gao, Yue.,Liu, Xi.,Chen, Weiting.,...&Li, Sheng.(2018).Antagonistic actions of juvenile hormone and 20-hydroxyecdysone within the ring gland determine developmental transitions in Drosophila.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(1),139-144.
MLA Liu, Suning,et al."Antagonistic actions of juvenile hormone and 20-hydroxyecdysone within the ring gland determine developmental transitions in Drosophila".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115.1(2018):139-144.
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