UM
Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene-Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules
Dong, Qian; Wang, Xuewei; Hu, Xiaoxiao; Xiao, Langqiu; Zhang, Liang; Song, Lijuan; Xu, Minglu; Zou, Yuxiu; Chen, Long; Chen, Zhuo; Tan, Weihong
2018-01-02
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume57Issue:1Pages:177-181
AbstractPhotothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was developed to deliver enhanced PTT and simultaneously inhibit PTT-induced inflammatory response. 1-Pyrene methanol was utilize to synthesize the anti-inflammatory prodrug pyrene-aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the prodrug on gold nanorod (AuNR)-encapsulated graphitic nanocapsule (AuNR@G), a photothermal agent, through pi-pi interactions. Such AuNR@G-P-aspirin complexes were used for near-infrared laser-triggered photothermal ablation of solid tumor and simultaneous inhibition of PTT-induced inflammation through the release of aspirin in tumor milieu. This strategy showed excellent effects invitro and in vivo.
Keywordaspirin graphitic nanocapsules inflammation photothermal therapy prodrugs
DOI10.1002/anie.201709648
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000418798600016
PublisherWILEY-V C H VERLAG GMBH
The Source to ArticleWOS
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Cited Times [WOS]:37   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Dong, Qian,Wang, Xuewei,Hu, Xiaoxiao,et al. Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene-Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(1):177-181.
APA Dong, Qian.,Wang, Xuewei.,Hu, Xiaoxiao.,Xiao, Langqiu.,Zhang, Liang.,...&Tan, Weihong.(2018).Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene-Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(1),177-181.
MLA Dong, Qian,et al."Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene-Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.1(2018):177-181.
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