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Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil
Li N.3; Lin Z.3; Chen W.3; Zheng Y.3; Ming Y.2; Zheng Z.2; Huang W.2; Chen L.2; Xiao J.3; Lin H.3
2018-09-01
Source PublicationFood and Chemical Toxicology
ISSN18736351 02786915
Volume119Pages:133-140
AbstractCorilagin content from different parts of longan (Dimocarpus longan Lour.) was determined by ultra performance liquid chromatography (UPLC) method. Additionally, the potential synergistic effects of corilagin + ginsenoside Rh2 (Rh2), and corilagin + 5-fluorouracil (5-FU) on ovarian cancer cells, and cancer-preventing activities, including inhibition of tyrosinase, properties of antioxidant and nitrite-scavenging, and blocking of nitrosamine synthesis were investigated. The results showed the content of corilagin from different parts of longan varied widely, while corilagin content in longan seed was high with a value of 542.15 ± 10.30 μg/g. Then the corilagin from longan seed was chosen for further study, since longan seed was easily obtained from by-product of longan fruit processing with low cost. Furthermore, the combinations of corilagin + Rh2, and corilagin + 5-FU showed an increased synergistic cytotoxicity on SKOv3ip and Hey cells. Moreover, corilagin inhibited exhibited effects of inhibiting tyrosinase, antioxidation, scavenging nitrite and blocking nitrosamine synthesis.
Keyword5-Fluorouracil Bioactivity Corilagin Ginsenoside Rh2 Longan seed Synergistic effect
DOI10.1016/j.fct.2018.05.018
URLView the original
Language英語
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Fujian Institute of Subtropical Botany
2.Key Laboratory of Xiamen City for Plant Introduction & Quarantine and Plant Derived Product
3.Fujian Agriculture and Forestry University
Recommended Citation
GB/T 7714
Li N.,Lin Z.,Chen W.,et al. Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil[J]. Food and Chemical Toxicology,2018,119:133-140.
APA Li N..,Lin Z..,Chen W..,Zheng Y..,Ming Y..,...&Lin H..(2018).Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil.Food and Chemical Toxicology,119,133-140.
MLA Li N.,et al."Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil".Food and Chemical Toxicology 119(2018):133-140.
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