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Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil
Li N.1,2; Lin Z.1,2; Chen W.1,2; Zheng Y.1,2; Ming Y.2,3; Zheng Z.2,3; Huang W.2,3; Chen L.2,3; Xiao J.1; Lin H.1
2018-09-01
Source PublicationFood and Chemical Toxicology
ISSN18736351 02786915
Volume119Pages:133-140
Abstract

Corilagin content from different parts of longan (Dimocarpus longan Lour.) was determined by ultra performance liquid chromatography (UPLC) method. Additionally, the potential synergistic effects of corilagin + ginsenoside Rh2 (Rh2), and corilagin + 5-fluorouracil (5-FU) on ovarian cancer cells, and cancer-preventing activities, including inhibition of tyrosinase, properties of antioxidant and nitrite-scavenging, and blocking of nitrosamine synthesis were investigated. The results showed the content of corilagin from different parts of longan varied widely, while corilagin content in longan seed was high with a value of 542.15 ± 10.30 μg/g. Then the corilagin from longan seed was chosen for further study, since longan seed was easily obtained from by-product of longan fruit processing with low cost. Furthermore, the combinations of corilagin + Rh2, and corilagin + 5-FU showed an increased synergistic cytotoxicity on SKOv3ip and Hey cells. Moreover, corilagin inhibited exhibited effects of inhibiting tyrosinase, antioxidation, scavenging nitrite and blocking nitrosamine synthesis.

Keyword5-fluorouracil Bioactivity Corilagin Ginsenoside Rh2 Longan Seed Synergistic Effect
DOI10.1016/j.fct.2018.05.018
URLView the original
Indexed BySCIE
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000443664200017
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXiao J.; Lin H.
Affiliation1.College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
2.Key Laboratory of Xiamen City for Plant Introduction & Quarantine and Plant Derived Product, Xiamen Overseas Chinese Subtropical Plant Introduction Garden, Xiamen, Fujian 361002, China
3.Key Laboratory of Fujian Province for Physiology and Biochemistry of Subtropical Plant, Fujian Institute of Subtropical Botany, Xiamen, Fujian 361006, China
Recommended Citation
GB/T 7714
Li N.,Lin Z.,Chen W.,et al. Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil[J]. Food and Chemical Toxicology,2018,119:133-140.
APA Li N..,Lin Z..,Chen W..,Zheng Y..,Ming Y..,...&Lin H..(2018).Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil.Food and Chemical Toxicology,119,133-140.
MLA Li N.,et al."Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil".Food and Chemical Toxicology 119(2018):133-140.
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