UM
Effects of chitosan pentamer and chitosan hexamer in vivo and in vitro on gene expression and secretion of cytokines
Wei X.3; Wang Y.3; Zhu Q.1; Xiao J.3; Xia W.2
2009-09-01
Source PublicationFood and Agricultural Immunology
ISSN09540105 14653443
Volume20Issue:3Pages:269-280
AbstractEffects of chitosan pentamer ((GLcN)) and chitosan hexamer ((GLcN)) in vivo and in vitro on gene transcription and protein translation of interleukin-1 (IL-1), tumour necrosis, factor alpha (TNF-α), interleukin-2 and interferon-γ (IFN-γ) were investigated by relatively quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. The results showed that the expression of IL-1 mRNA, TNF-α mRNA, IFN-γ mRNA as well as the secretion of IL-1, TNF-α and IFN-γ can both be promoted by (GLcN) and (GLcN). The promotion effects caused by (GLcN) were greater than that of (GLcN). Gene transcription and protein secretion of cytokines were promoted by (GLcN) and (GLcN) in vivo and in vitro and thus the immuno-modulating ability was promoted. This may be one of the molecular mechanisms for elucidation of immunity of chitooligosaccharides. © 2009 Taylor & Francis.
KeywordChitosan hexamer Chitosan pentamer Cytokines Gene expression Secretion
DOI10.1080/09540100903168157
URLView the original
Language英語
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Nantong University
2.Jiangnan University
3.Shanghai Normal University
Recommended Citation
GB/T 7714
Wei X.,Wang Y.,Zhu Q.,et al. Effects of chitosan pentamer and chitosan hexamer in vivo and in vitro on gene expression and secretion of cytokines[J]. Food and Agricultural Immunology,2009,20(3):269-280.
APA Wei X.,Wang Y.,Zhu Q.,Xiao J.,&Xia W..(2009).Effects of chitosan pentamer and chitosan hexamer in vivo and in vitro on gene expression and secretion of cytokines.Food and Agricultural Immunology,20(3),269-280.
MLA Wei X.,et al."Effects of chitosan pentamer and chitosan hexamer in vivo and in vitro on gene expression and secretion of cytokines".Food and Agricultural Immunology 20.3(2009):269-280.
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