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Structure-affinity relationship of flavones on binding to serum albumins: Effect of hydroxyl groups on ring A
Xiao J.3; Cao H.2; Wang Y.3; Yamamoto K.1; Wei X.3
2010-07-01
Source PublicationMolecular Nutrition and Food Research
ISSN16134125 16134133
Volume54Issue:SUPPL. 2
AbstractFour flavones (flavone, 7-hydroxyflavone, chrysin, and baicalein) sharing the same B- and C-ring structure but a different numbers of hydroxyl groups on the A-ring were studied for their affinities for BSA and HSA. The hydroxylation on ring A of flavones increased the binding constants (K ) and the number of binding sites (n) between flavones and serum albumins. The affinities of 7-hydroxyflavone for BSA and HSA were about 800 times and 40 times higher than that of flavone, respectively. It appears that the optimal number of hydroxyl groups introduced to the ring A of flavones is one. As more hydroxyl groups were introduced to positions at C-5, C-6, and/or C-7 of flavones, the affinities for serum albumins decrease. The critical energy transfer distances (R ) between the hydroxylated flavones (1-3 OH on the ring A) and serum albumins decreased with the increasing affinities for serum albumins. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keyword7-Hydroxyflavone Baicalein Chrysin Flavone Serum albumins
DOI10.1002/mnfr.200900454
URLView the original
Language英語
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Cited Times [WOS]:95   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Okayama Prefectural University
2.Nantong University
3.Shanghai Normal University
Recommended Citation
GB/T 7714
Xiao J.,Cao H.,Wang Y.,et al. Structure-affinity relationship of flavones on binding to serum albumins: Effect of hydroxyl groups on ring A[J]. Molecular Nutrition and Food Research,2010,54(SUPPL. 2).
APA Xiao J.,Cao H.,Wang Y.,Yamamoto K.,&Wei X..(2010).Structure-affinity relationship of flavones on binding to serum albumins: Effect of hydroxyl groups on ring A.Molecular Nutrition and Food Research,54(SUPPL. 2).
MLA Xiao J.,et al."Structure-affinity relationship of flavones on binding to serum albumins: Effect of hydroxyl groups on ring A".Molecular Nutrition and Food Research 54.SUPPL. 2(2010).
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