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A suspending-droplet mode paper-based microfluidic platform for low-cost, rapid, and convenient detection of lead(II) ions in liquid solution
Sun, Han1; Li, Wanbo1; Dong, Zhen-Zhen1; Hu, Chong1; Leung, Chung-Hang2; Ma, Dik-Lung1,3; Ren, Kangning1,3,4
2018-01-15
Source PublicationBIOSENSORS & BIOELECTRONICS
ISSN0956-5663
Volume99Pages:361-367
Abstract

A paper-based microfluidic device based on unconventional principle was developed and used to detect lead ions through a two-step process including heated incubation and subsequent mixing. The device was made by generating a superhydrophobic pattern, which defines channel and reservoir barriers, on a water-impermeable paper substrate, followed by loading and drying the reagents in the defined reservoirs. Different from the conventional paper-based devices that are made of water-permeable paper, the as-prepared device holds watet drops in discrete reservoirs, and the water drops will not move unless the device is titled along the direction of the predefined channels. In this way, the liquid samples applied onto the device are handled as individual drops and could be stored, transported, and mixed on demand. Different from the conventional paper-based devices that use capillary force to drive liquid, our new device uses wetting and gravity as driving force. We name this operation principle suspending -droplet mode paper-based device (SD-pPAD). The use of a Teflon contact printing stamp makes the production of such devices rapid, cost efficient, and mass productive. Utilizing a Gquadruplex-based luminescence switch-on assay, we demonstrated rapid, convenient, highly sensitive, and low cost detection of lead(II) ions in water samples, using a custom made battery-powered portable device, and a smart phone as the detector.

KeywordPaper-based Microfluidic Device Superhydrophobic Lead(Ii) Ion Iridium(Iii) Complex Smart Phone
DOI10.1016/j.bios.2017.07.073
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
WOS SubjectBiophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
WOS IDWOS:000413284200050
PublisherELSEVIER ADVANCED TECHNOLOGY
The Source to ArticleWOS
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLeung, Chung-Hang; Ma, Dik-Lung; Ren, Kangning
Affiliation1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.HKBU Institute of Research and Continuing Education, Shenzhen, China
4.State Key Laboratory of Environmental and Biological Analysis, The Hong Kong Baptist University, Waterloo Rd, Kowloon, Hong Kong, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Sun, Han,Li, Wanbo,Dong, Zhen-Zhen,et al. A suspending-droplet mode paper-based microfluidic platform for low-cost, rapid, and convenient detection of lead(II) ions in liquid solution[J]. BIOSENSORS & BIOELECTRONICS,2018,99:361-367.
APA Sun, Han.,Li, Wanbo.,Dong, Zhen-Zhen.,Hu, Chong.,Leung, Chung-Hang.,...&Ren, Kangning.(2018).A suspending-droplet mode paper-based microfluidic platform for low-cost, rapid, and convenient detection of lead(II) ions in liquid solution.BIOSENSORS & BIOELECTRONICS,99,361-367.
MLA Sun, Han,et al."A suspending-droplet mode paper-based microfluidic platform for low-cost, rapid, and convenient detection of lead(II) ions in liquid solution".BIOSENSORS & BIOELECTRONICS 99(2018):361-367.
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