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Chemical characterization and immunomodulatory activity of acetylated polysaccharides from Dendrobium devonianum
Deng, Yong; Li, Min; Chen, Ling-Xiao; Chen, Xian-Qiang; Lu, Jia-Hong; Zhao, Jing; Li, Shao-Ping
2018-01-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume180Pages:238-245
AbstractThe chain conformation, chemical characters and immunomodulatory activity of polysaccharide from Dendrobium devonianum (DDP) were investigated. Results showed that molecular weights, polydispersity index, radius of gyrations of DDP were 3.99 x 10(5) Da 1.27, 74.1 nm, respectively. By applying the polymer solution theory, the exponent (v) values of (1/2)(z) = kM(w)(v) was calculated as 0.38, which revealed that DDP existed as a globular shape in aqueous solution, and further confirmed by AFM analysis. Furthermore, the main monosaccharide compositions were Man and Glc with the ratio of 29.61:1.00. Indeed, the main glycosidic linkages were beta-1,4-Manp, and substituted with acetyl groups at O-2 and O-3 position. Notably, DDP could promote the immune functions of macrophages including NO release and phagocytosis. Thus, DDP could be explored as a natural immune-stimulating agent in the health and functional food area as well as pharmaceutical industries.
KeywordDendrobium devonianum Chain conformation Saccharide mapping Immunomodulatory activity
DOI10.1016/j.carbpol.2017.10.026
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000416369800028
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Deng, Yong,Li, Min,Chen, Ling-Xiao,et al. Chemical characterization and immunomodulatory activity of acetylated polysaccharides from Dendrobium devonianum[J]. CARBOHYDRATE POLYMERS,2018,180:238-245.
APA Deng, Yong.,Li, Min.,Chen, Ling-Xiao.,Chen, Xian-Qiang.,Lu, Jia-Hong.,...&Li, Shao-Ping.(2018).Chemical characterization and immunomodulatory activity of acetylated polysaccharides from Dendrobium devonianum.CARBOHYDRATE POLYMERS,180,238-245.
MLA Deng, Yong,et al."Chemical characterization and immunomodulatory activity of acetylated polysaccharides from Dendrobium devonianum".CARBOHYDRATE POLYMERS 180(2018):238-245.
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