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Pb2+, Cu2+, Zn2+, Mg2+ and mn2+ reduce the affinities of flavone, genistein and kaempferol for human serum albumin in vitro
Yang F.; Wang J.; Liu C.; Xu X.; Li W.; Xia Z.; Xiao J.
2011-08-11
Source PublicationArchives of Biological Sciences
ISSN03544664
Volume63Issue:3Pages:623-634
AbstractFlavone (Fl), genistein (Gen) and kaempferol (Kol) were studied for their affinities towards human serum albumin (HSA) in the presence and absence of Pb,Cu,Zn,Mg and Mn. The fluorescence intensities of HSA decreased with increasing concentration of the three flavonoids. Kaempferol resulted in a blue-shift of the λ of HSA from 336 to 330 nm; flavone showed an obvious red-shift of the λ of HSA from 336 to 342 nm; genistein did not cause an obvious blue-shift or red-shift of the λ of HSA. However, the extents of λ-shifts induced by the flavonoids in the presence of metal ions were much bigger than that in the absence of mental ions. Pb,Cu,Zn,Mg and Mn reduced the quenching constants of the flavonoids for HSA by 14.6% to 60.7%, 28% to 67.9%,3.5% to 59.4%, 23.2% to 63.7% and 14% to 65%, respectively. The affinities of flavone, genistein and kaempferol for HSA decreased about 10.84%, 10.05%and 3.56% in the presence of Pb2, respectively. Cu2 decreased the affinities of flavone, genistein and kaempferol for HSA about 14.04%, 5.14%and 8.89%, respectively. Zn2 decreased the affinities of flavone, genistein and kaempferol for HSA about 3.79%, 0.55% and 3.58%, respectively. Mg decreased the affinities of flavone, genistein and kaempferol for HSA about 16.94%, 2.94%and 7.04%, respectively. Mn2 decreased the affinities of flavone, genistein and kaempferol for HSA about 14.24%, 3.66% and 4.78%, respectively.
KeywordCu2+ Flavone Genistein Human serum albumin Kaempferol Mg2+ Mn2+ Pb2+ Zn2+
DOI10.2298/ABS1103623Y
URLView the original
Language英語
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被引频次[WOS]:7   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题University of Macau
AffiliationShanghai Normal University
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Yang F.,Wang J.,Liu C.,et al. Pb2+, Cu2+, Zn2+, Mg2+ and mn2+ reduce the affinities of flavone, genistein and kaempferol for human serum albumin in vitro[J]. Archives of Biological Sciences,2011,63(3):623-634.
APA Yang F..,Wang J..,Liu C..,Xu X..,Li W..,...&Xiao J..(2011).Pb2+, Cu2+, Zn2+, Mg2+ and mn2+ reduce the affinities of flavone, genistein and kaempferol for human serum albumin in vitro.Archives of Biological Sciences,63(3),623-634.
MLA Yang F.,et al."Pb2+, Cu2+, Zn2+, Mg2+ and mn2+ reduce the affinities of flavone, genistein and kaempferol for human serum albumin in vitro".Archives of Biological Sciences 63.3(2011):623-634.
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