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Noncovalent interaction of dietary polyphenols with common human plasma proteins
Xiao J.1,2; Zhao Y.1; Wang H.3; Yuan Y.3; Yang F.1; Zhang C.1; Yamamoto K.2
Source PublicationJournal of Agricultural and Food Chemistry
ISSN00218561 15205118

Common human plasma proteins (CHPP), also called blood proteins, are proteins found in blood plasma. The molecular structure/property-affinity relationships of dietary polyphenols noncovalently binding to CHPP were investigated by comparing the binding constants obtained from the fluorescence titration method. An additional methoxy group in flavonoids increased their binding affinities for CHPP by 1.05 to 72.27 times. The hydroxylation on the 4′ position (ring B) of flavones and flavonols and the 5 position (ring A) of isoflavones weakened the binding affinities; however, the hydroxylation on other positions of flavonoids slightly enhanced or little affected the binding affinities for CHPP. The glycosylation of flavonoids weakened or slightly affected the affinities for CHPP by 1 order of magnitude. The hydrogenation of the C2=C3 double bond of flavone, 6-hydroxyflavone, 6-methoxyflavone and myricetin decreased the binding affinities about 10.02 to 17.82 times. The galloylation of catechins significantly improved the binding affinities with CHPP about 10 to 1000 times. The esterification of gallic acid increased its binding affinity. The binding affinities with CHPP were strongly influenced by the structural differences of dietary polyphenols. Polyphenols with higher affinities for purified HSA also showed stronger affinities with CHPP. The hydrophobic force played an important role in binding interaction between polyphenols and CHPP. 

KeywordCommon Human Plasma Proteins Molecular Property-affinity Relationship Polyphenols Protein-polyphenol Noncovalent Interaction Structure-affinity Relationship
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Indexed BySCIE
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000295488000044
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Cited Times [WOS]:70   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXiao J.
Affiliation1.‎ Shanghai Normal Univ, Dept Biol, Coll Life & Environm Sci, Shanghai 200234, Peoples R China
2.Okayama Prefectural Univ, Dept Nutr, Fac Hlth & Welf, Okayama, Japan
3.Shanghai Dahua Hosp, Shanghai 200237, Peoples R China
Recommended Citation
GB/T 7714
Xiao J.,Zhao Y.,Wang H.,et al. Noncovalent interaction of dietary polyphenols with common human plasma proteins[J]. Journal of Agricultural and Food Chemistry,2011,59(19):10747-10754.
APA Xiao J..,Zhao Y..,Wang H..,Yuan Y..,Yang F..,...&Yamamoto K..(2011).Noncovalent interaction of dietary polyphenols with common human plasma proteins.Journal of Agricultural and Food Chemistry,59(19),10747-10754.
MLA Xiao J.,et al."Noncovalent interaction of dietary polyphenols with common human plasma proteins".Journal of Agricultural and Food Chemistry 59.19(2011):10747-10754.
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