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Noncovalent interaction of dietary polyphenols with common human plasma proteins
Xiao J.3; Zhao Y.3; Wang H.2; Yuan Y.2; Yang F.3; Zhang C.3; Yamamoto K.1
2011-10-12
Source PublicationJournal of Agricultural and Food Chemistry
ISSN00218561 15205118
Volume59Issue:19Pages:10747-10754
AbstractCommon human plasma proteins (CHPP), also called blood proteins, are proteins found in blood plasma. The molecular structure/property-affinity relationships of dietary polyphenols noncovalently binding to CHPP were investigated by comparing the binding constants obtained from the fluorescence titration method. An additional methoxy group in flavonoids increased their binding affinities for CHPP by 1.05 to 72.27 times. The hydroxylation on the 4′ position (ring B) of flavones and flavonols and the 5 position (ring A) of isoflavones weakened the binding affinities; however, the hydroxylation on other positions of flavonoids slightly enhanced or little affected the binding affinities for CHPP. The glycosylation of flavonoids weakened or slightly affected the affinities for CHPP by 1 order of magnitude. The hydrogenation of the C2=C3 double bond of flavone, 6-hydroxyflavone, 6-methoxyflavone and myricetin decreased the binding affinities about 10.02 to 17.82 times. The galloylation of catechins significantly improved the binding affinities with CHPP about 10 to 1000 times. The esterification of gallic acid increased its binding affinity. The binding affinities with CHPP were strongly influenced by the structural differences of dietary polyphenols. Polyphenols with higher affinities for purified HSA also showed stronger affinities with CHPP. The hydrophobic force played an important role in binding interaction between polyphenols and CHPP. © 2011 American Chemical Society.
Keywordcommon human plasma proteins molecular property-affinity relationship polyphenols protein-polyphenol noncovalent interaction structure-affinity relationship
DOI10.1021/jf2029829
URLView the original
Language英語
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Cited Times [WOS]:59   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Okayama Prefectural University
2.Dahua Hospital
3.Shanghai Normal University
Recommended Citation
GB/T 7714
Xiao J.,Zhao Y.,Wang H.,et al. Noncovalent interaction of dietary polyphenols with common human plasma proteins[J]. Journal of Agricultural and Food Chemistry,2011,59(19):10747-10754.
APA Xiao J..,Zhao Y..,Wang H..,Yuan Y..,Yang F..,...&Yamamoto K..(2011).Noncovalent interaction of dietary polyphenols with common human plasma proteins.Journal of Agricultural and Food Chemistry,59(19),10747-10754.
MLA Xiao J.,et al."Noncovalent interaction of dietary polyphenols with common human plasma proteins".Journal of Agricultural and Food Chemistry 59.19(2011):10747-10754.
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