Noncovalent interaction of dietary polyphenols with common human plasma proteins

doi:10.1021/jf2029829

	Noncovalent interaction of dietary polyphenols with common human plasma proteins
	Xiao J.3; Zhao Y.3; Wang H.2; Yuan Y.2; Yang F.3; Zhang C.3; Yamamoto K.1
	2011-10-12
Source Publication	Journal of Agricultural and Food Chemistry
ISSN	00218561 15205118
Volume	59 Issue:19 Pages:10747-10754
Abstract	Common human plasma proteins (CHPP), also called blood proteins, are proteins found in blood plasma. The molecular structure/property-affinity relationships of dietary polyphenols noncovalently binding to CHPP were investigated by comparing the binding constants obtained from the fluorescence titration method. An additional methoxy group in flavonoids increased their binding affinities for CHPP by 1.05 to 72.27 times. The hydroxylation on the 4′ position (ring B) of flavones and flavonols and the 5 position (ring A) of isoflavones weakened the binding affinities; however, the hydroxylation on other positions of flavonoids slightly enhanced or little affected the binding affinities for CHPP. The glycosylation of flavonoids weakened or slightly affected the affinities for CHPP by 1 order of magnitude. The hydrogenation of the C2=C3 double bond of flavone, 6-hydroxyflavone, 6-methoxyflavone and myricetin decreased the binding affinities about 10.02 to 17.82 times. The galloylation of catechins significantly improved the binding affinities with CHPP about 10 to 1000 times. The esterification of gallic acid increased its binding affinity. The binding affinities with CHPP were strongly influenced by the structural differences of dietary polyphenols. Polyphenols with higher affinities for purified HSA also showed stronger affinities with CHPP. The hydrophobic force played an important role in binding interaction between polyphenols and CHPP. © 2011 American Chemical Society.
Keyword	common human plasma proteins molecular property-affinity relationship polyphenols protein-polyphenol noncovalent interaction structure-affinity relationship
DOI	10.1021/jf2029829
URL	View the original
Language	英語
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics	Cited Times [WOS]:59 [WOS Record] [Related Records in WOS]
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Okayama Prefectural University 2.Dahua Hospital 3.Shanghai Normal University
Recommended Citation GB/T 7714	Xiao J.,Zhao Y.,Wang H.,et al. Noncovalent interaction of dietary polyphenols with common human plasma proteins[J]. Journal of Agricultural and Food Chemistry,2011,59(19):10747-10754.
APA	Xiao J..,Zhao Y..,Wang H..,Yuan Y..,Yang F..,...&Yamamoto K..(2011).Noncovalent interaction of dietary polyphenols with common human plasma proteins.Journal of Agricultural and Food Chemistry,59(19),10747-10754.
MLA	Xiao J.,et al."Noncovalent interaction of dietary polyphenols with common human plasma proteins".Journal of Agricultural and Food Chemistry 59.19(2011):10747-10754.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh