UM
Multifunctional PHPMA-Derived Polymer for Ratiometric pH Sensing, Fluorescence Imaging, and Magnetic Resonance Imaging
Su, Fengyu; Agarwal, Shubhangi; Pan, Tingting; Qiao, Yuan; Zhang, Liqiang; Shi, Zhengwei; Kong, Xiangxing; Day, Kevin; Chen, Meiwan; Meldrum, Deirdre; Kodibagkar, Vikram D.; Tian, Yanqing
2018-01-17
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:2Pages:1556-1565
AbstractIn this paper, we report synthesis and characterization of a novel multimodality (MRI/fluorescence) probe for pH sensing and imaging. A multifunctional polymer was derived from poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and integrated with a naphthalimide-based-ratiometric fluorescence probe and a gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complex (Gd-DOTA complex). The polymer was characterized using UV-vis absorption spectrophotometry, fluorescence spectrofluorophotometry, magnetic resonance imaging (MRI), and confocal microscopy for optical and MRI-based pH sensing and cellular imaging. In vitro labeling of macrophage J774 and esophageal CP-A cell lines shows the polymer's ability to be internalized in the cells. The transverse relaxation time (T-2) of the polymer was observed to be pH-dependent, whereas the spin-lattice relaxation time (T-1) was not. The pH probe in the polymer shows a strong fluorescence-based ratiometric pH response with emission window changes, exhibiting blue emission under acidic conditions and green emission under basic conditions, respectively. This study provides new materials with multimodalities for pH sensing and imaging.
Keywordpolymer pH sensor ratiometric sensor MRI fluorescence imaging dual-modality
DOI10.1021/acsami.7b15796
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000423140400012
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Su, Fengyu,Agarwal, Shubhangi,Pan, Tingting,et al. Multifunctional PHPMA-Derived Polymer for Ratiometric pH Sensing, Fluorescence Imaging, and Magnetic Resonance Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(2):1556-1565.
APA Su, Fengyu.,Agarwal, Shubhangi.,Pan, Tingting.,Qiao, Yuan.,Zhang, Liqiang.,...&Tian, Yanqing.(2018).Multifunctional PHPMA-Derived Polymer for Ratiometric pH Sensing, Fluorescence Imaging, and Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,10(2),1556-1565.
MLA Su, Fengyu,et al."Multifunctional PHPMA-Derived Polymer for Ratiometric pH Sensing, Fluorescence Imaging, and Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 10.2(2018):1556-1565.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Su, Fengyu]'s Articles
[Agarwal, Shubhangi]'s Articles
[Pan, Tingting]'s Articles
Baidu academic
Similar articles in Baidu academic
[Su, Fengyu]'s Articles
[Agarwal, Shubhangi]'s Articles
[Pan, Tingting]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Su, Fengyu]'s Articles
[Agarwal, Shubhangi]'s Articles
[Pan, Tingting]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.