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Influences of glucose on the dietary hydroxyflavonoid-plasma protein interaction
Wang Y.2; Zhao Y.2; Yang F.2; Yuan Y.1; Wang H.1; Xiao J.2
2012-12-12
Source PublicationJournal of Agricultural and Food Chemistry
ISSN00218561 15205118
Volume60Issue:49Pages:12116-12121
AbstractThe influence of glucose on the interaction between flavonoids and plasma proteins from healthy humans (HPPs) was investigated. Glucose affected the flavonoid-protein interactions depending upon their structures. Glucose significantly reduced the affinities of HPPs for 6-hydroxyflavone by 10.72 times, slightly weakened the affinities of HPPs for quercetin, 7-hydroxyflavone, and kaempferol, and hardly affected the affinities of HPPs for myricetin, chrysin, and 3,7-dihydroxyflavone on the first day. However, glucose obviously enhanced the affinities of HPPs for 3-hydroxyflavone, luteolin, and apigenin. Glucose significantly weakened the binding affinities of HPPs for chrysin, kaempferol, quercetin, and myricetin by 6.17, 7.94, 14.12, and 112.2 times, when kept at 37 C under air conditions for 14 days, and the binding affinities of HPPs for 7-hydroxyflavone, luteolin, 3,7-dihydroxyflavone, 3-hydroxyflavone, and 6-hydroxyflavone were slightly decreased by 1.35-, 1.58-, 1.58-, 1.9-, and 2.4-fold. The binding affinity between apigenin and HPP was hardly influenced. Glucose weakened the binding affinities of HPPs for hydroxyflavonoids. The differences between log K(absence) and log K(presence) were bigger for the more lipophilic hydroxyflavonoids, and more lipophilic hydroxyflavonoids are easily affected by glucose, when kept at 37 C under air conditions for 14 days. These flavonoids with lower hydrogen donor/acceptor numbers prefer to stably interact with HPPs in the presence of glucose. However, other flavonoids with high hydrogen donor/acceptor numbers (multi-hydroxyl flavonoids) were apt to reduce their affinities with HPPs in the presence of glucose. © 2012 American Chemical Society.
Keywordantioxidant binding affinity glucose human plasma proteins multi-hydroxyl flavonoids
DOI10.1021/jf303094e
URLView the original
Language英語
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Dahua Hospital
2.Shanghai Normal University
Recommended Citation
GB/T 7714
Wang Y.,Zhao Y.,Yang F.,et al. Influences of glucose on the dietary hydroxyflavonoid-plasma protein interaction[J]. Journal of Agricultural and Food Chemistry,2012,60(49):12116-12121.
APA Wang Y.,Zhao Y.,Yang F.,Yuan Y.,Wang H.,&Xiao J..(2012).Influences of glucose on the dietary hydroxyflavonoid-plasma protein interaction.Journal of Agricultural and Food Chemistry,60(49),12116-12121.
MLA Wang Y.,et al."Influences of glucose on the dietary hydroxyflavonoid-plasma protein interaction".Journal of Agricultural and Food Chemistry 60.49(2012):12116-12121.
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