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Seeing the unseen of Chinese herbal medicine processing (Paozhi): advances in new perspectives
Wu, Xu1; Wang, Shengpeng2; Lu, Junrong3,4; Jing, Yong3; Li, Mingxing1; Cao, Jiliang2; Bian, Baolin5; Hu, Changjiang3
Source PublicationCHINESE MEDICINE

Processing (Paozhi) represents a unique Chinese pharmaceutic technique to facilitate the use of Chinese herbal medicines (CHMs) for a specific clinical need in the guidance of Traditional Chinese Medicine (TCM) theory. Traditionally, most CHMs require a proper processing to meet the needs of specific clinical syndromes before being prescribed by TCM practitioners. During processing, significant changes in chemical profiles occur, which inevitably influence the associated pharmacological properties of a CHM. However, although processing is formed in a long-term practice, the underlying mechanisms remain unclear for most CHMs. The deepening understanding of the mechanism of processing would provide scientific basis for standardization of processing. This review introduced the role of processing in TCM and several typical methods of processing. We also summarized the up-to-date efforts on the mechanistic study of CHM processing. The processing mechanisms mainly include the following aspects: (i) directly reducing contents of toxic constituents; (ii) structural transformation of constituents; (iii) improving solubility of constituents; (iv) physically changing the existing form of constituents; (v) and influence by excipients. These progress may give new insights into future researches.

KeywordProcessing Chinese Herbal Medicines Decoction Pieces Standardization Mechanism
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Indexed BySCI
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000422731300001
The Source to ArticleWOS
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China
4.West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China
5.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
Recommended Citation
GB/T 7714
Wu, Xu,Wang, Shengpeng,Lu, Junrong,et al. Seeing the unseen of Chinese herbal medicine processing (Paozhi): advances in new perspectives[J]. CHINESE MEDICINE,2018,13.
APA Wu, Xu.,Wang, Shengpeng.,Lu, Junrong.,Jing, Yong.,Li, Mingxing.,...&Hu, Changjiang.(2018).Seeing the unseen of Chinese herbal medicine processing (Paozhi): advances in new perspectives.CHINESE MEDICINE,13.
MLA Wu, Xu,et al."Seeing the unseen of Chinese herbal medicine processing (Paozhi): advances in new perspectives".CHINESE MEDICINE 13(2018).
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