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Cytotoxic, antitumor and immunomodulatory effects of the water-soluble polysaccharides from lotus (Nelumbo nucifera Gaertn.) seeds
Zheng Y.4; Wang Q.4; Zhuang W.4; Lu X.4; Miron A.2; Chai T.-T.3; Zheng B.4; Xiao J.5
2016-11-01
Source PublicationMolecules
ISSN14203049
Volume21Issue:11
AbstractLotus is an edible and medicinal plant, and the extracts from its different parts exhibit various bioactivities. In the present study, the hot water-soluble polysaccharides from lotus seeds (LSPS) were evaluated for their cancer cell cytotoxicity, immunomodulatory and antitumor activities. LSPS showed significant inhibitory effects on the mouse gastric cancer MFC cells, human liver cancer HuH-7 cells and mouse hepatocarcinoma H22 cells. The animal studies showed that LSPS inhibited tumor growth in H22 tumor-bearing mice with the highest inhibition rate of 45.36%, which is comparable to that induced by cyclophosphamide (30 mg/kg) treatment (50.79%). The concentrations of white blood cells were significantly reduced in cyclophosphamide-treated groups (p < 0.01), while LSPS showed much fewer side effects according to the hematology analysis. LSPS improved the immune response in H22 tumor-bearing mice by enhancing the spleen and thymus indexes, and increasing the levels of serum cytokines including tumor necrosis factor-α and interleukin-2. Moreover, LSPS also showed in vivo antioxidant activity by increasing superoxide dismutase activity, thus reducing the malondialdehyde level in the liver tissue. These results suggested that LSPS can be used as an antitumor and immunomodulatory agent.
KeywordAntitumor Immunomodulatory Lotus seeds Polysaccharides
DOI10.3390/molecules21111465
URLView the original
Language英語
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Fujian Academy of Agricultural Sciences
2.Universitatea de Medicina si Farmacie Grigore T. Popa din Iasi
3.Universiti Tunku Abdul Rahman
4.Fujian Agriculture and Forestry University
5.Universidade de Macau
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GB/T 7714
Zheng Y.,Wang Q.,Zhuang W.,et al. Cytotoxic, antitumor and immunomodulatory effects of the water-soluble polysaccharides from lotus (Nelumbo nucifera Gaertn.) seeds[J]. Molecules,2016,21(11).
APA Zheng Y..,Wang Q..,Zhuang W..,Lu X..,Miron A..,...&Xiao J..(2016).Cytotoxic, antitumor and immunomodulatory effects of the water-soluble polysaccharides from lotus (Nelumbo nucifera Gaertn.) seeds.Molecules,21(11).
MLA Zheng Y.,et al."Cytotoxic, antitumor and immunomodulatory effects of the water-soluble polysaccharides from lotus (Nelumbo nucifera Gaertn.) seeds".Molecules 21.11(2016).
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