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Cytotoxic, antitumor and immunomodulatory effects of the water-soluble polysaccharides from lotus (Nelumbo nucifera Gaertn.) seeds
Zheng Y.1; Wang Q.1,2; Zhuang W.1; Lu X.1; Miron A.3; Chai T.-T.4; Zheng B.1; Xiao J.5
2016-11-01
Source PublicationMolecules
ISSN14203049
Volume21Issue:11
Abstract

Lotus is an edible and medicinal plant, and the extracts from its different parts exhibit various bioactivities. In the present study, the hot water-soluble polysaccharides from lotus seeds (LSPS) were evaluated for their cancer cell cytotoxicity, immunomodulatory and antitumor activities. LSPS showed significant inhibitory effects on the mouse gastric cancer MFC cells, human liver cancer HuH-7 cells and mouse hepatocarcinoma H22 cells. The animal studies showed that LSPS inhibited tumor growth in H22 tumor-bearing mice with the highest inhibition rate of 45.36%, which is comparable to that induced by cyclophosphamide (30 mg/kg) treatment (50.79%). The concentrations of white blood cells were significantly reduced in cyclophosphamide-treated groups (p < 0.01), while LSPS showed much fewer side effects according to the hematology analysis. LSPS improved the immune response in H22 tumor-bearing mice by enhancing the spleen and thymus indexes, and increasing the levels of serum cytokines including tumor necrosis factor-α and interleukin-2. Moreover, LSPS also showed in vivo antioxidant activity by increasing superoxide dismutase activity, thus reducing the malondialdehyde level in the liver tissue. These results suggested that LSPS can be used as an antitumor and immunomodulatory agent.

KeywordAntitumor Immunomodulatory Lotus Seeds Polysaccharides
DOI10.3390/molecules21111465
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000389918200047
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China
2.Fujian Acad Agr Sci, Inst Agr Engn, Fuzhou 350003, Peoples R China
3.Grigore T Popa Univ Med & Pharm Iasi, Fac Pharm, Univ St 16, Iasi 700115, Romania
4.Univ Tunku Abdul Rahman, Fac Sci, Dept Chem Sci, Jalan Univ Bandar Barat, Kampar 31900, Perak, Malaysia
5.Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Taipa, Macau, Peoples R China
Recommended Citation
GB/T 7714
Zheng Y.,Wang Q.,Zhuang W.,et al. Cytotoxic, antitumor and immunomodulatory effects of the water-soluble polysaccharides from lotus (Nelumbo nucifera Gaertn.) seeds[J]. Molecules,2016,21(11).
APA Zheng Y..,Wang Q..,Zhuang W..,Lu X..,Miron A..,...&Xiao J..(2016).Cytotoxic, antitumor and immunomodulatory effects of the water-soluble polysaccharides from lotus (Nelumbo nucifera Gaertn.) seeds.Molecules,21(11).
MLA Zheng Y.,et al."Cytotoxic, antitumor and immunomodulatory effects of the water-soluble polysaccharides from lotus (Nelumbo nucifera Gaertn.) seeds".Molecules 21.11(2016).
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