UM
Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells
Chen J.2; Tian J.2; Ge H.2; Liu R.1; Xiao J.2
2017-11-01
Source PublicationFood and Chemical Toxicology
ISSN18736351 02786915
Volume109Pages:930-940
AbstractTetramethylpyrazine is a bioactive compound found in Chinese black vinegar. This work is to investigate the potential effects of tetramethylpyrazine on intracellular cholesterol modulation in HepG2 cells. The results demonstrated that tetramethylpyrazine can induce intracellular cholesterol efflux. Tetramethylpyrazine may also improve endothelial function through its antioxidant effects by inhibiting reactive oxygen species levels and increasing the antioxidant enzymes superoxide dismutase and catalase. Tetramethylpyrazine increased liver X receptor and peroxisome proliferator-activated receptor gene expression in HepG2 cells. Protein expression of ATP-binding cassette transporter 1 was up-regulated in a dose-dependent manner (P < 0.05). The biological significance of tetramethylpyrazine may involve hypolipidemic effects via modulation of intracellular cholesterol efflux, ROS inhibition, increases in SOD and CAT activities, and direct regulation of PPAR and LXR gene expression. Tetramethylpyrazine may improve lipid profiles by elevating the PPARγ-LXRα-ABCA1 pathway.
KeywordAnti-oxidation Cholesterol efflux Hypolipidemic Liver X receptor Peroxisome proliferator-activated receptor Tetramethylpyrazine
DOI10.1016/j.fct.2016.12.017
URLView the original
Language英語
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Cornell University
2.Fujian Agriculture and Forestry University
3.Universidade de Macau
Recommended Citation
GB/T 7714
Chen J.,Tian J.,Ge H.,et al. Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells[J]. Food and Chemical Toxicology,2017,109:930-940.
APA Chen J.,Tian J.,Ge H.,Liu R.,&Xiao J..(2017).Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells.Food and Chemical Toxicology,109,930-940.
MLA Chen J.,et al."Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells".Food and Chemical Toxicology 109(2017):930-940.
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