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Chemical composition, antioxidant and anti-tyrosinase activities of fractions from Stenoloma chusanum
Wu S.2; Li J.2; Wang Q.2; Cao J.2; Yu H.3; Cao H.3; Xiao J.2
2017-11-15
Source PublicationIndustrial Crops and Products
ISSN09266690
Volume107Pages:539-545
AbstractStenoloma chusanum is a traditional Chinese medicine with very high total flavonoid content (TFC) and the total phenolic content (TPC). To explore its phytochemicals and potential in therapeutic applications, the antioxidant activity and tyrosinase inhibitory activity of S. chusanum fractions prepared by extraction with petroleum ether (PF), chloroform (CF), ethyl acetate (EF), n-butanol (NF) and water fractions (WF) as well as their flavonoid profiles were investigated. All these five fractions contained appreciable quantities of flavonoids and phenols, but the EF fraction was richest one with TPC and TFC values of 385.5 mg gallic acid equivalents/g and 746.8 mg rutin equivalents/g, respectively. The EF, NF, and CF fractions showed significant antioxidant activity, presumably due to their high flavonoid and phenol contents. All five fractions also caused dose-dependent inhibition of tyrosinase activity, and the PF fraction was a stronger inhibitor than the positive control inhibitor arbutin. However, the compounds responsible for this activity are currently unknown. These fractions’ chemical profiles were analyzed by LC/MS, revealing that their most abundant secondary metabolites were flavonoids and alkaloids. The EF and NF fractions contained similar compounds, including flavonols, flavones, isoquinolines, filicinic acid, and gigantecine. Further work on S. chusanum to isolate these compounds and explain the mechanisms responsible for their antioxidant activity and anti-tyrosinase activity is warranted.
KeywordAnti-tyrosinase activity Antioxidant activity Stenoloma chusanum Total flavonoid and phenol
DOI10.1016/j.indcrop.2017.04.033
URLView the original
Language英語
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Key Laboratory of Plant Functional Genomics and Resources
2.Shanghai Normal University
3.Universidade de Macau
Recommended Citation
GB/T 7714
Wu S.,Li J.,Wang Q.,et al. Chemical composition, antioxidant and anti-tyrosinase activities of fractions from Stenoloma chusanum[J]. Industrial Crops and Products,2017,107:539-545.
APA Wu S..,Li J..,Wang Q..,Cao J..,Yu H..,...&Xiao J..(2017).Chemical composition, antioxidant and anti-tyrosinase activities of fractions from Stenoloma chusanum.Industrial Crops and Products,107,539-545.
MLA Wu S.,et al."Chemical composition, antioxidant and anti-tyrosinase activities of fractions from Stenoloma chusanum".Industrial Crops and Products 107(2017):539-545.
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