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Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system
Smeriglio A.4; Alloisio S.1; Raimondo F.M.2; Denaro M.4; Xiao J.5; Cornara L.3; Trombetta D.4
2018-09-01
Source PublicationFood and Chemical Toxicology
ISSN18736351 02786915
Volume119Pages:407-416
AbstractThe use of essential oils (EOs) is known since long time in traditional medicine and aromatherapy for the management of various oxidative stress-related disorders and has been further increased recently for their neuroprotective and anti-aging potentials as well as for reducing anxiety and stress. The purpose of this work was to evaluate, for the first time, the chemical composition of Citrus lumia Risso EO and its antioxidant, anti-cholinesterase, and neuroactive properties by cell-free and cell-based assays. The EO has shown strong antioxidant and free radical scavenging properties, particularly in hydrogen atom transfer based assays (β-carotene bleaching and ORAC, IC 22 μg/mL and 46 μg/mL, respectively), that can be attributed to the high content of monoterpenes, especially D-Limonene (48.905%), and Linalool (18.245%). Furthermore, the EO has shown an interesting anti-acetylcholinesterase activity (IC 258.25 μg/mL). Data from MTT analysis indicate that the cytotoxicity of EO, evaluated on L929 mouse fibroblasts, is very low, with an IC higher than 500 μg/mL at 48 h. Rat neuronal networks subjected to EO showed a concentration-dependent inhibition of spontaneous electrical activity. Results indicate that C. lumia EO could be an important source of natural antioxidants suggesting an important preventive role in the onset of oxidative stress-related pathologies.
KeywordAnti-cholinesterase activity Antioxidant properties Citrus lumia Risso Cytotoxicity Essential oil Neuroactive effects
DOI10.1016/j.fct.2017.12.053
URLView the original
Language英語
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.ETT Spa
2.Università degli Studi di Palermo
3.Università degli Studi di Genova
4.Università degli Studi di Messina
5.Universidade de Macau
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GB/T 7714
Smeriglio A.,Alloisio S.,Raimondo F.M.,et al. Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system[J]. Food and Chemical Toxicology,2018,119:407-416.
APA Smeriglio A..,Alloisio S..,Raimondo F.M..,Denaro M..,Xiao J..,...&Trombetta D..(2018).Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system.Food and Chemical Toxicology,119,407-416.
MLA Smeriglio A.,et al."Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system".Food and Chemical Toxicology 119(2018):407-416.
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