UM
Preparation and anti-tumor activity study of long-circulating, self-assembled gambogic acid nanoparticles 藤黄酸长循环纳米粒的制备及其抗肿瘤作用研究
Guo M.-R.1; Wang F.1; Chen L.-J.1; Ouyang D.-F.3; Liu Y.1; Liang X.1; Zhang G.-L.1; Zhang J.-F.1; Liu H.-S.2
2018-07-30
Source PublicationChinese Journal of New Drugs
ISSN10033734
Volume27Issue:14Pages:1639-1644
AbstractObjective:To synthesize amphiphilic triblock polymer polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) as carriers of gambogic acid (GA) and study its preparation process, antitumor activity and pharmacokinetics. Methods:The PCL-PEG-PCL was synthesized by polymerization reaction and was used as nanoparticle materials to obtain GA-loaded nanoparticles. The encapsulation efficiency,particle size,release rate and anti-tumor activities in vitro were investigated. Results:The particle size of nanoparticles with optimal formulation and process was around 226.5 nm and the PDI was 0.208. The encapsulation efficiency was above 92%. The release of GA-loaded nanoparticles was less than 40% in 0.5 h and showed no obvious burst release. The cell inhibition rate of GA-loaded micelles was lower than that of GA after 24 h but higher than it after 36 h. Conclusion:The GA-loaded nanoparticles demonstrated good long-circulating activities and slow-release characteristic in vitro and the GA-loaded nanoparticles showed good anti-tumor activities.
KeywordAnti-tumor Gambogic acid Nanoparticles PCL-PEG-PCL
URLView the original
Language中文
Fulltext Access
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Liaoning University
2.Research Center for Computer Simulating and Information Processing of Bio-macromolecules of Liaoning Province
3.Universidade de Macau
Recommended Citation
GB/T 7714
Guo M.-R.,Wang F.,Chen L.-J.,等. Preparation and anti-tumor activity study of long-circulating, self-assembled gambogic acid nanoparticles 藤黄酸长循环纳米粒的制备及其抗肿瘤作用研究[J]. Chinese Journal of New Drugs,2018,27(14):1639-1644.
APA Guo M.-R..,Wang F..,Chen L.-J..,Ouyang D.-F..,Liu Y..,...&Liu H.-S..(2018).Preparation and anti-tumor activity study of long-circulating, self-assembled gambogic acid nanoparticles 藤黄酸长循环纳米粒的制备及其抗肿瘤作用研究.Chinese Journal of New Drugs,27(14),1639-1644.
MLA Guo M.-R.,et al."Preparation and anti-tumor activity study of long-circulating, self-assembled gambogic acid nanoparticles 藤黄酸长循环纳米粒的制备及其抗肿瘤作用研究".Chinese Journal of New Drugs 27.14(2018):1639-1644.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo M.-R.]'s Articles
[Wang F.]'s Articles
[Chen L.-J.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo M.-R.]'s Articles
[Wang F.]'s Articles
[Chen L.-J.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo M.-R.]'s Articles
[Wang F.]'s Articles
[Chen L.-J.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.