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Systematic review on the efficacy and safety of herbal medicines for Alzheimer's disease
Man S.C.2; Durairajan S.S.K.2; Kum W.F.2; Lu J.H.2; Huang J.D.3; Cheng C.F.2; Chung V.1; Xu M.2; Li M.2
2008
Source PublicationJournal of Alzheimer's Disease
ISSN13872877
Volume14Issue:2Pages:209-223
AbstractA systematic review was conducted to assess the efficacy and safety of herbal medications (HM), as either monotherapy or adjunct to orthodox medications (cholinesterase inhibitors and nootropic agents, OM) for Alzheimer's disease (AD). Sixteen studies testing different HM were included. Out of the 15 HM monotherapy studies, 13 reported HM to be significantly better than OM or placebo; one reported similar efficacy between HM and OM. Only the HM adjuvant study reported significant efficacy. No major adverse events for HM were reported and HMs were found to reduce the adverse effects arising from OM. Imbalance in ethnicity among participants was observed; gender distribution was unclear. Heterogeneity in diagnostic criteria, interventions and outcome measures hindered comprehensive data analysis. Studies comparing HM with OM suggest that HM can be a safe, effective treatment for AD, either alone or in conjunction with OM. Methodological flaws in the design of the studies, however, limited the extent to which the results could be interpreted. Among various HMs, the safety and tolerability of EGb761 was best established. Further multi-center trials with large sample size, high methodological qualities and standardized HM ingredients are necessary for clinical recommendations on the use of HM in treating AD. © 2008 - IOS Press and the authors. All rights reserved.
KeywordAlzheimer's disease Clinical trial Herbal medicine Systematic review
DOI10.3233/JAD-2008-14209
URLView the original
Language英語
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Chinese University of Hong Kong
2.Hong Kong Baptist University
3.The University of Hong Kong Li Ka Shing Faculty of Medicine
Recommended Citation
GB/T 7714
Man S.C.,Durairajan S.S.K.,Kum W.F.,et al. Systematic review on the efficacy and safety of herbal medicines for Alzheimer's disease[J]. Journal of Alzheimer's Disease,2008,14(2):209-223.
APA Man S.C..,Durairajan S.S.K..,Kum W.F..,Lu J.H..,Huang J.D..,...&Li M..(2008).Systematic review on the efficacy and safety of herbal medicines for Alzheimer's disease.Journal of Alzheimer's Disease,14(2),209-223.
MLA Man S.C.,et al."Systematic review on the efficacy and safety of herbal medicines for Alzheimer's disease".Journal of Alzheimer's Disease 14.2(2008):209-223.
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