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The effect of salvianolic acid B combined with laminar shear stress on TNF-α-stimulated adhesion molecule expression in human aortic endothelial cells
Xie L.X.1; Durairajan S.S.K.1; Lu J.H.1; Liu C.L.4; Kum W.F.1; Wang Y.1; Koo I.1; Wu W.K.3; Han D.2; Lao F.2; Huang J.-D.4; Li M.1
2010
Source PublicationClinical Hemorheology and Microcirculation
ISSN13860291
Volume44Issue:4Pages:245-258
AbstractThe study was conducted to investigate the effect of Salvianolic acid B (Sal B) on TNF-α-stimulated adhesion molecule expression i.e. vascular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin in human aortic endothelial cells (HAECs) under laminar shear stress (LSS) condition. Exposure of HAECs to LSS (12 dynes/cm2 for 6 h decreased the TNF-α-induced protein expression of adhesion molecules i.e. VCAM-1, ICAM-1 and E-selectin. Pre-treatment of HAECs with Sal B (10 μg/ml) then exposed to LSS (12 dynes/cm2) for 6 h significantly inhibited VCAM-1, ICAM-1 and E-selectin expression stimulated by TNF-α. Moreover, combined Sal B and LSS treatment inhibited the adhesiveness of monocytic U937 cells to TNF-α-stimulated HAECs. We further examined the molecular mechanisms and found that the combination of Sal B and LSS treatment dramatically inhibited TNF-α-induced NF-κB activation evidenced by IκBα degradation and p65 nuclear translocation in HAECs. This study provides the first biomechanopharmacological evidence that Sal B has a combination effect with LSS to reduce the expression of three adhesion molecules, leading to reduced monocyte adhesion to HAECs, at least in part, by inhibiting the NF-κB signaling pathway. Data from this study thus support the potential clinical application of Sal B in vascular inflammatory diseases. © 2010 - IOS Press and the authors. All rights reserved.
Keywordadhesion molecules IκBα laminar shear stress NF-κB salvianolic acid B TNF-α
DOI10.3233/CH-2010-1269
URLView the original
Language英語
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被引频次[WOS]:14   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist University
2.National Center for Nanoscience and Technology Beijing
3.Sun Yat-Sen University, Zhongshan School of Medicine
4.The University of Hong Kong Li Ka Shing Faculty of Medicine
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Xie L.X.,Durairajan S.S.K.,Lu J.H.,et al. The effect of salvianolic acid B combined with laminar shear stress on TNF-α-stimulated adhesion molecule expression in human aortic endothelial cells[J]. Clinical Hemorheology and Microcirculation,2010,44(4):245-258.
APA Xie L.X..,Durairajan S.S.K..,Lu J.H..,Liu C.L..,Kum W.F..,...&Li M..(2010).The effect of salvianolic acid B combined with laminar shear stress on TNF-α-stimulated adhesion molecule expression in human aortic endothelial cells.Clinical Hemorheology and Microcirculation,44(4),245-258.
MLA Xie L.X.,et al."The effect of salvianolic acid B combined with laminar shear stress on TNF-α-stimulated adhesion molecule expression in human aortic endothelial cells".Clinical Hemorheology and Microcirculation 44.4(2010):245-258.
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