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Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake
Lin L.1; Nuotio-Antar A.M.1; Ma X.1; Liu F.2; Fiorotto M.L.1; Sun Y.1
2014
Source PublicationJournal of Nutrition
ISSN15416100 00223166
Volume144Issue:9Pages:1349-1355
AbstractAging is often associated with overweight and obesity. There exists a long-standing debate about whether meal pattern also contributes to the development of obesity. The orexigenic hormone ghrelin regulates appetite and satiety by activating its receptor, growth hormone secretagogue receptor (GHS-R). In mice, circulating ghrelin concentrations and brain GHS-R expression were shown to increase with aging. To assess whether GHS-R regulates feeding pattern during aging, we studied meal patterns for the following cohorts of male mice fed a normal unpurified diet: 1) 3-4 mo, young wild-type (WT) mice; 2) 3-4 mo, young Ghsr-null (Ghsr) mice; 3) 12-14 mo, middle-aged WT (WT-M) mice; 4) 12-14 mo, middle-aged Ghsr (Ghsr-M) mice; 5) 24-26 mo, old WT (WT-O) mice; and 6) 24-26 mo, old Ghsr (Ghsr-O) mice. Although the total daily food intake of Ghsr mice was similar to that of WT controls, Ghsr-M and Ghsr-O mice had 9% (P = 0.07) and 16% (P < 0.05) less body weight compared with WT-M and WT-O mice, respectively, primarily due to reduced fat mass (P < 0.05, WT-M vs. Ghsr-M and WT-O vs. Ghsr-O). Intriguingly, Ghsr-M mice ate largermeals (on average, Ghsr-M mice ate 0.117g/meal andWT-Mmice ate 0.080 g/meal; P < 0.01) and took a longer time to eat (Ghsr-M, 196.0 s andWT-M, 128.9 s; P < 0.01), but ate less frequently (Ghsr-M, 31.0 times/d and WT-M, 42.3 times/d; P < 0.05) than WT-M controls. In addition, we found that expression of hypothalamic orexigenic peptides, neuropeptide Y (NPY) and agouti-related peptide (AgRP), was relatively lower in aged WT mice (P = 0.09 for NPY and P = 0.06 for AgRP), but anorexic peptide pro-opiomelanocortin (POMC) expression remained unchanged between theWT age groups. Interestingly, old Ghsr mice had greater hypothalamic NPY expression (102% higher; P<0.05) and AgRP expression (P = 0.07) but significantly lower POMC expression (P < 0.05) when compared with age-matchedWT-O controls. Thus, our results indicate that GHS-R plays an important role in the regulation ofmeal pattern and that GHS-R ablation maymodulate feeding behavior through the regulation of hypothalamic neuropeptides. Our results collectively suggest that ghrelin receptor antagonism may have a beneficial effect on metabolism during aging.
DOI10.3945/jn.114.191171
URLView the original
Language英語
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.USDA ARS Children's Nutrition Research Center
2.University of Texas Health Science Center at San Antonio
3.Baylor College of Medicine
4.Second Xiangya Hospital of Central-South University
5.First Affiliated Hospital of Zhengzhou University
6.Universidade de Macau
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GB/T 7714
Lin L.,Nuotio-Antar A.M.,Ma X.,et al. Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake[J]. Journal of Nutrition,2014,144(9):1349-1355.
APA Lin L.,Nuotio-Antar A.M.,Ma X.,Liu F.,Fiorotto M.L.,&Sun Y..(2014).Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake.Journal of Nutrition,144(9),1349-1355.
MLA Lin L.,et al."Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake".Journal of Nutrition 144.9(2014):1349-1355.
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