UM  > Institute of Chinese Medical Sciences
Novel diterpenoids from the twigs of Podocarpus nagi
Zheng Y.-D.3; Guan X.-C.1; Li D.4; Wang A.-Q.4; Ke C.-Q.3; Tang C.-P.3; Lin L.-G.4; Ye Y.3; Wang Z.-L.1; Yao S.3
2016-10-01
Source PublicationMolecules
ISSN14203049
Volume21Issue:10
Abstract

Phytochemical investigation of the twigs of Podocarpus nagi (Podocarpaceae) led to the isolation of two new abietane-type diterpenoids, named 1β,16-dihydroxylambertic acid (1) and 3β,16-dihydroxylambertic acid (2), along with two new ent-pimarane-type diterpenoids, named ent-2β,15,16,18-tetrahydroxypimar-8(14)-ene (3) and ent-15-oxo-2β,16,18-trihydroxypimar-8(14)-ene (4). Their respective structures were elucidated on the basis of spectroscopic analyses, including 1D- and 2D-NMR, IR, CD, and HR-ESI-MS. This is the first time ent-pimarane-type diterpenoids from the genus Podocarpus has been reported. All four new compounds were tested for cytotoxic activity. The MTT assay results showed that compounds 3 and 4 significantly inhibited the proliferation of human cervical cancer Hela cells, human lung cancer A549 cells, and human breast cancer MCF-7 cells at a concentration of 10 μM. Furthermore, using the lipopolysaccharide (LPS)-stimulated RAW264.7 cells, compounds 2 and 4 were found to significantly inhibit nitrogen oxide (NO) production with IC values of 26.5 ± 6.1 and 17.1 ± 1.5 μM, respectively.

KeywordAbietane-type Diterpenoid Anti-inflammation Cytotoxicity Ent-pimarane-type Diterpenoid Podocarpus Nagi
DOI10.3390/molecules21101282
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000389917900019
Fulltext Access
Citation statistics
Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Yangtze University
2.University of Chinese Academy of Sciences
3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences
4.Universidade de Macau
5.ShanghaiTech University
Recommended Citation
GB/T 7714
Zheng Y.-D.,Guan X.-C.,Li D.,et al. Novel diterpenoids from the twigs of Podocarpus nagi[J]. Molecules,2016,21(10).
APA Zheng Y.-D..,Guan X.-C..,Li D..,Wang A.-Q..,Ke C.-Q..,...&Yao S..(2016).Novel diterpenoids from the twigs of Podocarpus nagi.Molecules,21(10).
MLA Zheng Y.-D.,et al."Novel diterpenoids from the twigs of Podocarpus nagi".Molecules 21.10(2016).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zheng Y.-D.]'s Articles
[Guan X.-C.]'s Articles
[Li D.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zheng Y.-D.]'s Articles
[Guan X.-C.]'s Articles
[Li D.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zheng Y.-D.]'s Articles
[Guan X.-C.]'s Articles
[Li D.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.