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Novel diterpenoids from the twigs of Podocarpus nagi
Zheng Y.-D.3; Guan X.-C.1; Li D.4; Wang A.-Q.4; Ke C.-Q.3; Tang C.-P.3; Lin L.-G.4; Ye Y.3; Wang Z.-L.1; Yao S.3
Source PublicationMolecules

Phytochemical investigation of the twigs of Podocarpus nagi (Podocarpaceae) led to the isolation of two new abietane-type diterpenoids, named 1β,16-dihydroxylambertic acid (1) and 3β,16-dihydroxylambertic acid (2), along with two new ent-pimarane-type diterpenoids, named ent-2β,15,16,18-tetrahydroxypimar-8(14)-ene (3) and ent-15-oxo-2β,16,18-trihydroxypimar-8(14)-ene (4). Their respective structures were elucidated on the basis of spectroscopic analyses, including 1D- and 2D-NMR, IR, CD, and HR-ESI-MS. This is the first time ent-pimarane-type diterpenoids from the genus Podocarpus has been reported. All four new compounds were tested for cytotoxic activity. The MTT assay results showed that compounds 3 and 4 significantly inhibited the proliferation of human cervical cancer Hela cells, human lung cancer A549 cells, and human breast cancer MCF-7 cells at a concentration of 10 μM. Furthermore, using the lipopolysaccharide (LPS)-stimulated RAW264.7 cells, compounds 2 and 4 were found to significantly inhibit nitrogen oxide (NO) production with IC values of 26.5 ± 6.1 and 17.1 ± 1.5 μM, respectively.

KeywordAbietane-type Diterpenoid Anti-inflammation Cytotoxicity Ent-pimarane-type Diterpenoid Podocarpus Nagi
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Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000389917900019
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Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Yangtze University
2.University of Chinese Academy of Sciences
3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences
4.Universidade de Macau
5.ShanghaiTech University
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GB/T 7714
Zheng Y.-D.,Guan X.-C.,Li D.,et al. Novel diterpenoids from the twigs of Podocarpus nagi[J]. Molecules,2016,21(10).
APA Zheng Y.-D..,Guan X.-C..,Li D..,Wang A.-Q..,Ke C.-Q..,...&Yao S..(2016).Novel diterpenoids from the twigs of Podocarpus nagi.Molecules,21(10).
MLA Zheng Y.-D.,et al."Novel diterpenoids from the twigs of Podocarpus nagi".Molecules 21.10(2016).
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