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Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity
Niu B.1; Ke C.-Q.1; Li B.-H.3; Li Y.2; Yi Y.2; Luo Y.2; Shuai L.3; Yao S.1; Lin L.-G.4; Li J.3; Ye Y.1
2017-05-26
Source PublicationJournal of Natural Products
ISSN15206025 01633864
Volume80Issue:5Pages:1428-1435
Abstract

Seven new cucurbitane glucosides, 11-oxomogrosides III E and IV (1 and 2), 11-oxoisomogroside V (3), 7-oxomogrosides III E and IV (4 and 5), and mogrosides VI A and VI B (6 and 7), were separated from the crude extract of Siraitia grosvenorii. The new structures were defined by analysis of their H and C NMR, 2D NMR, and HRESIMS data. Especially, the band-selective constant time HSQC and band-selective constant time HMBC techniques were recuited to elucidate the structures of the complex glucoside moieties. Using the PGC-1α promoter driven luciferase reporter assay, the isolated compounds were examined for PGC-1α promoter activity.

DOI10.1021/acs.jnatprod.6b01086
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000402498300024
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYe Y.
Affiliation1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2.Guilin Layn Natural Ingredients Corp.
3.University of Chinese Academy of Sciences
4.Universidade de Macau
5.ShanghaiTech University
Recommended Citation
GB/T 7714
Niu B.,Ke C.-Q.,Li B.-H.,et al. Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity[J]. Journal of Natural Products,2017,80(5):1428-1435.
APA Niu B..,Ke C.-Q..,Li B.-H..,Li Y..,Yi Y..,...&Ye Y..(2017).Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity.Journal of Natural Products,80(5),1428-1435.
MLA Niu B.,et al."Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity".Journal of Natural Products 80.5(2017):1428-1435.
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