UM  > 中華醫藥研究院
A dual-functional luminescent probe for imaging H2S in living zebrafish and discrimination hypoxic cells from normoxic cells
Wang, Wanhe1; Wu, Chun1; Yang, Chao2; Li, Guodong2; Han, Quan-Bin3; Li, Shengnan2; Lee, Simon Ming-Yuen2; Leung, Chung-Hang2; Ma, Dik-Lung1
2018-02
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
ISSN0925-4005
Volume255Pages:1953-1959
Abstract

In this work, we present a new reaction-based luminogenic probe with dual functions: a highly selective sensor for both in vitro H2S sensing and in vivo H2S imaging in living zebrafish, and a luminescent agent for imaging hypoxic cells. The mechanism of this platform is based on the reduction of the nitro group in the iridium(III) complex to an amino group, which turns on its luminescence. Complex 1 exhibited a linear range of detection for H2S from 0 to 170 M with a detection limit of 4.35 M. Complex 1 also shows the ability to detect H2S in HeLa cells and in living zebrafish. Meanwhile, complex 1 is capable of discriminating hypoxic from normoxic cells, and shows potential for monitoring hypoxia in zebrafish model.

KeywordHydrogen Sulfide Iridium(Iii) Complex Sensor Luminescence
DOI10.1016/j.snb.2017.08.222
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Electrochemistry ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS IDWOS:000414319900093
PublisherELSEVIER SCIENCE SA
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong, Peoples R China
2.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
3.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Wanhe,Wu, Chun,Yang, Chao,et al. A dual-functional luminescent probe for imaging H2S in living zebrafish and discrimination hypoxic cells from normoxic cells[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,255:1953-1959.
APA Wang, Wanhe.,Wu, Chun.,Yang, Chao.,Li, Guodong.,Han, Quan-Bin.,...&Ma, Dik-Lung.(2018).A dual-functional luminescent probe for imaging H2S in living zebrafish and discrimination hypoxic cells from normoxic cells.SENSORS AND ACTUATORS B-CHEMICAL,255,1953-1959.
MLA Wang, Wanhe,et al."A dual-functional luminescent probe for imaging H2S in living zebrafish and discrimination hypoxic cells from normoxic cells".SENSORS AND ACTUATORS B-CHEMICAL 255(2018):1953-1959.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Wanhe]'s Articles
[Wu, Chun]'s Articles
[Yang, Chao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Wanhe]'s Articles
[Wu, Chun]'s Articles
[Yang, Chao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Wanhe]'s Articles
[Wu, Chun]'s Articles
[Yang, Chao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.